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Investigation of Allium Sativum's Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model

dc.authorid Ekin, Suat/0000-0002-6502-5028
dc.authorid Kaya, Cihan/0000-0003-4175-7694
dc.authorid Ozdemir, Hulya/0000-0002-6045-8342
dc.authorid Guney, Gurhan/0000-0002-0093-2743
dc.authorscopusid 56593323000
dc.authorscopusid 55194255000
dc.authorscopusid 16310940800
dc.authorscopusid 25230277800
dc.authorscopusid 6602257873
dc.authorscopusid 7004290487
dc.authorwosid Yildirim, Serkan/Aah-6721-2020
dc.authorwosid Ekin, Suat/Aar-2193-2020
dc.authorwosid Kaya, Cihan/F-8883-2013
dc.authorwosid Guney, Gurhan/R-1454-2018
dc.contributor.author Guney, Gurhan
dc.contributor.author Kaya, Cihan
dc.contributor.author Yildirim, Serkan
dc.contributor.author Oto, Gokhan
dc.contributor.author Ekin, Suat
dc.contributor.author Ozdemir, Hulya
dc.date.accessioned 2025-05-10T17:58:12Z
dc.date.available 2025-05-10T17:58:12Z
dc.date.issued 2018
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Guney, Gurhan] Sakarya Univ, Educ & Res Hosp, Dept Obstet & Gynecol, Sakarya, Turkey; [Kaya, Cihan] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Obstet & Gynecol, Istanbul, Turkey; [Yildirim, Serkan] Ataturk Univ, Fac Vet Med, Dept Pathol, Erzurum, Turkey; [Oto, Gokhan; Ozdemir, Hulya] Yuzuncu Yil Univ, Fac Med, Dept Pharmacol, Van, Turkey; [Ekin, Suat] Yuzuncu Yil Univ, Fac Sci, Dept Biochem, Van, Turkey en_US
dc.description Ekin, Suat/0000-0002-6502-5028; Kaya, Cihan/0000-0003-4175-7694; Ozdemir, Hulya/0000-0002-6045-8342; Guney, Gurhan/0000-0002-0093-2743 en_US
dc.description.abstract We aimed to evaluate the effects of detorsion and Allium sativum (garlic oil) treatment on the ovarian reserve in an ovarian torsion model. Ovarian torsion may lead to loss of ovarian tissue and infertility. It is an experimental rat study that was carried out on 16 sets of ovaries each, one for treatment group and a control group. In the control group, the procedure involved only the surgically opening and closing the abdomen. Bilateral adnexal torsion/detorsion was performed after a 3-hour ischemia period for the detorsion-only group.The detorsion + Allium sativum group received a 5 ml/kg dose of Allium sativum intraperitoneally, 2 hours before surgery. After the second surgery removed ovarian samples were evaluated for follicle counts, damage scores and other parameters. Primordial, preantral, small antral and large antral follicle counts were significantly higher in the detorsion + Allium sativum group. Degeneration, congestion, hemorrhage ,inflammation and total damage scores were significantly elevated in the detorsion only group compared to those for the detorsion + Allium sativum group. Finally, there was a significant correlation between AMH alterations and postoperative, preantral follicle count (p<0.05). As a conclusion detorsion + Allium sativum treatment may be effective in protecting the ovarian reserve after torsion. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.4067/S0717-95022018000200395
dc.identifier.endpage 401 en_US
dc.identifier.issn 0717-9502
dc.identifier.issn 0717-9367
dc.identifier.issue 2 en_US
dc.identifier.scopus 2-s2.0-85049785694
dc.identifier.scopusquality Q3
dc.identifier.startpage 395 en_US
dc.identifier.uri https://doi.org/10.4067/S0717-95022018000200395
dc.identifier.uri https://hdl.handle.net/20.500.14720/20307
dc.identifier.volume 36 en_US
dc.identifier.wos WOS:000438815300003
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Soc Chilena Anatomia en_US
dc.relation.ispartof International Journal of Morphology en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Anti-Mullerian Hormone en_US
dc.subject Detorsion en_US
dc.subject Allium Sativum en_US
dc.subject Ovarian Reserve en_US
dc.subject Oxidative Stress en_US
dc.title Investigation of Allium Sativum's Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model en_US
dc.type Article en_US

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