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Comparative Effects of Carvedilol and Lercanidipine on Ultrafiltration and Solute Transport in Capd Patients

dc.authorid Reha, Erkoc/0009-0001-7230-8843
dc.authorid Topal, Cevat/0000-0001-7539-8066
dc.contributor.author Topal, Cevat
dc.contributor.author Erkoc, Reha
dc.contributor.author Sayarlioglu, Hayriye
dc.contributor.author Dogan, Ekrem
dc.contributor.author Beyenik, Huseyin
dc.date.accessioned 2025-05-10T17:26:57Z
dc.date.available 2025-05-10T17:26:57Z
dc.date.issued 2009
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Sayarlioglu, Hayriye; Dogan, Ekrem] Sutcu Imam Univ, Dept Nephrol, Kahramanmaras, Turkey; [Topal, Cevat] Trabzon Training & Res Hosp, Dept Nephrol, Trabzon, Turkey; [Erkoc, Reha] Yuzuncu Yil Univ, Dept Nephrol, Van, Turkey; [Beyenik, Huseyin] Yuzuncu Yil Univ, Dept Internal Med, Van, Turkey en_US
dc.description Reha, Erkoc/0009-0001-7230-8843; Topal, Cevat/0000-0001-7539-8066 en_US
dc.description.abstract Background. Peritonitis, the type of buffer used in the dialysate, continue ambulatory peritoneal dialysis (CAPD) of greater than two years duration, increased exposure to dialysate glucose, diabetes mellitus, and the use of beta blockers may contribute to impaired ultrafiltration. Objectives. The aim of the present study is to compare the effects of a calcium-channel blocker and a beta-blocker on the peritoneal transport and clearance. Methods. We studied 48 patients with ESRD on chronic peritoneal dialysis, included 27 females and 19 males with mean age 42.6 +/- 16.4 years. Two patients were excluded from the study due to peritonitis. Patients were treated either with carvedilol or lercanidipine. In all patients; peritoneal equilibration test ( PET), ultrafiltration (UF), Kt/V ratio, creatinine clearance (CrCl), systolic blood pressure, diastolic blood pressure, serum BUN, creatinine, glucose, sodium, potassium, albumin, cholesterol, and triglyceride values were obtained before and after 8 weeks from the start of the drug treatment. Results. Lercanidipine and carvedilol showed a good antihypertensive effect in CAPD patients. Both drugs had a good tolerability profile and showed no effect on plasma lipids. There were no differences in terms of PET, ultrafiltration, Kt/V ratio, CrCl, systolic blood pressure, diastolic blood pressure, serum BUN, creatinine, glucose, sodium, and potassium values between both patient groups. After antihypertensive treatment, neither group showed a difference in the above-mentioned parameters (p > 0.05) except potassium, which was significantly higher in the carvedilol group (p < 0.05). Conclusions. In CAPD patients. short-term usage of carvedilol has no effect on ultrafiltration and solute transport like lercanidipine. Both drugs showed a good antihypertensive effect. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1080/08860220902979364
dc.identifier.endpage 451 en_US
dc.identifier.issn 0886-022X
dc.identifier.issn 1525-6049
dc.identifier.issue 6 en_US
dc.identifier.pmid 20187715
dc.identifier.scopusquality Q2
dc.identifier.startpage 446 en_US
dc.identifier.uri https://doi.org/10.1080/08860220902979364
dc.identifier.uri https://hdl.handle.net/20.500.14720/11823
dc.identifier.volume 31 en_US
dc.identifier.wos WOS:000269006600004
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Taylor & Francis Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Carvedilol en_US
dc.subject Lercanidipine en_US
dc.subject Ultrafiltration And Solute Transport en_US
dc.subject Capd Patients en_US
dc.title Comparative Effects of Carvedilol and Lercanidipine on Ultrafiltration and Solute Transport in Capd Patients en_US
dc.type Article en_US

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