Synthesis of Ferrocene Based Naphthoquinones and Its Application as Novel Non-Enzymatic Hydrogen Peroxide

Abstract

At present, a highly sensitive hydrogen peroxide (H2O2) sensor is fabricated by ferrocene based naphthaquinone derivatives as 2,3-Diferrocenyl-1,4-naphthoquinone and 2-bromo-3-ferrocenyl-1,4-naphthoquinone. These ferrocene based naphthaquinone derivatives are characterized by H-NMR and C-NMR. The electrochemical properties of these ferrocene based naphthaquinone are investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) on modified glassy carbon electrode (GCE). The modified electrode with ferrocene based naphthaquinone derivatives exhibits an improved voltammetric response to the H2O2 redox reaction. 2-bromo-3-ferrocenyl-1,4-naphthoquinone show excellent non-enzymatic sensing ability towards H2O2 response with a detection limitation of 2.7 mu mol/L a wide detection range from 10 mu M to 400 mu M in H2O2 detection. The sensor also exhibits short response time (1 s) and good sensitivity of 71.4 mu A mM(-1) cm(-2) and stability. Furthermore, the DPV method exhibited very high sensitivity (18999 mu A mM(-1) cm(-2)) and low detection limit (0.66 mu M) compared to the CA method. Ferrocene based naphthaquinone derivative based sensors have a lower cost and high stability. Thus, this novel non-enzyme sensor has potential application in H2O2 detection.