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Antinociceptive and Anti-Inflammatory Activities of Viburnum Lantana

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Date

2007

Journal Title

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Volume Title

Publisher

Taylor & Francis Ltd

Abstract

Water extract of Viburnum lantana L. ( Caprifoliaceae) ( VL) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VL causes dose-related inhibition in acetic acid-induced abdominal stretching in mice. VL inhibited abdominal stretching at 100 mg/kg, which is similar to that of aspirin, but this extract exhibited stronger antinociceptive activity than aspirin at a 200 mg/kg dose. VL showed powerful antinociceptive activity, which was quantified by a tail-flick test in 100 mg/kg dose. The anti-inflammatory activity of VL was not found to be significantly different at doses of 100 and 200 mg/kg. As a result, VL had shown slight anti-inflammatory activity compared with indomethacin. The LD50 of VL was determined as 2.169 g/kg.

Description

Sever Yilmaz, Betul/0000-0003-2084-9514

Keywords

Anti-Inflammatory Activity, Antinociceptive Activity, Median Lethal Dose (Ld50), Viburnum Lantana

Turkish CoHE Thesis Center URL

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Source

Volume

45

Issue

3

Start Page

241

End Page

245