Antinociceptive and Anti-Inflammatory Activities of Viburnum Lantana
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Date
2007
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Ltd
Abstract
Water extract of Viburnum lantana L. ( Caprifoliaceae) ( VL) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VL causes dose-related inhibition in acetic acid-induced abdominal stretching in mice. VL inhibited abdominal stretching at 100 mg/kg, which is similar to that of aspirin, but this extract exhibited stronger antinociceptive activity than aspirin at a 200 mg/kg dose. VL showed powerful antinociceptive activity, which was quantified by a tail-flick test in 100 mg/kg dose. The anti-inflammatory activity of VL was not found to be significantly different at doses of 100 and 200 mg/kg. As a result, VL had shown slight anti-inflammatory activity compared with indomethacin. The LD50 of VL was determined as 2.169 g/kg.
Description
Sever Yilmaz, Betul/0000-0003-2084-9514
ORCID
Keywords
Anti-Inflammatory Activity, Antinociceptive Activity, Median Lethal Dose (Ld50), Viburnum Lantana
Turkish CoHE Thesis Center URL
WoS Q
Q1
Scopus Q
Q2
Source
Volume
45
Issue
3
Start Page
241
End Page
245