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Analysis of Phytochemical Composition and Biological Activities of Helichrysum Pallasii (Sprengel) Ledeb Leaves

dc.authorscopusid 58222207800
dc.authorscopusid 55624671000
dc.authorscopusid 57366492200
dc.authorscopusid 8411629800
dc.authorscopusid 55208137400
dc.contributor.author Işık, N.
dc.contributor.author Mukemre, M.
dc.contributor.author Turker, R.S.
dc.contributor.author Zengin, G.
dc.contributor.author Dalar, A.
dc.date.accessioned 2025-05-10T16:54:40Z
dc.date.available 2025-05-10T16:54:40Z
dc.date.issued 2023
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Işık N., Van Yuzuncu Yil University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Van, 65100, Turkey; Mukemre M., Hakkari University, Yuksekova Vocational School, Department of Plant and Animal Production, Hakkari, 30100, Turkey; Turker R.S., Van Yuzuncu Yil University, Faculty of Pharmacy, Department of Pharmacology, Van, 65100, Turkey; Zengin G., Selcuk University, Faculty of Science, Department of Biology, Konya, 42130, Turkey; Dalar A., Van Yuzuncu Yil University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Van, 65100, Turkey en_US
dc.description.abstract This study aimed at the investigation of in vitro biological activities (antioxidant and enzyme inhibition) and phytochemical composition of various extracts (ethanol maceration, aqueous infusion, and aqueous decoction) obtained from leaf organs of Helichrysum pallasii, which has been traditionally used as herbal tea and medicine in Eastern Anatolia. Experimental analysis showed that ethanol-based extract had higher total phenolic content (TPC: 103 mg GAE/gE) and showed superior antioxidant potentials (FRAP: 2205 μmol Fe2+/gE; ORAC: 2540 μmol Trolox Eq./gE; DPPH: IC50=0.58 mg/ml; CUPRAC: IC50=0.37 mg/ml; Phosphomolybdenum: IC50=1.34 mg/ml ve metal chelation: IC50=1.42 mg/ml) and enzyme inhibition (Acetylcholinesterase: IC50=1.49 mg/ml; Butyrylcholinesterase: IC50=1.98 mg/ml; Tyrosinase: IC50=0.68 mg/ml; Alpha-amylase: IC50=2.09 mg/ml; Alpha-glucosidase: IC50=0.51 mg/ml; and Pancreatic lipase: IC50=42.5 μg/ml) and contained higher amounts of phenolic (chlorogenic acid isomers and rutin) and fatty acid (palmitic, linoleic, and linolenic acids) compounds than traditional preparations (infusion and decoction). The current study's findings indicate that the leaves of the Helichrysum pallasii are a source of phytochemicals with strong antioxidant and enzyme inhibitory properties, implying that it could be a candidate for biotherapeutic agent research and development. © 2023 The authors. en_US
dc.identifier.doi 10.21448/ijsm.1132698
dc.identifier.endpage 85 en_US
dc.identifier.issn 2148-6905
dc.identifier.issue 1 en_US
dc.identifier.scopus 2-s2.0-85156273809
dc.identifier.scopusquality Q4
dc.identifier.startpage 71 en_US
dc.identifier.trdizinid 1193517
dc.identifier.uri https://doi.org/10.21448/ijsm.1132698
dc.identifier.uri https://hdl.handle.net/20.500.14720/3212
dc.identifier.volume 10 en_US
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Pamukkale University en_US
dc.relation.ispartof International Journal of Secondary Metabolite en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Antioxidant en_US
dc.subject Biotherapeutic en_US
dc.subject Enzyme Inhibition en_US
dc.subject Helichrysum Pallasii en_US
dc.subject Phenolics en_US
dc.title Analysis of Phytochemical Composition and Biological Activities of Helichrysum Pallasii (Sprengel) Ledeb Leaves en_US
dc.type Article en_US

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