Novel Cacao Oil-Based Organo-Hydrogels To Detect Carcinoma Antigen 125 in Serum Medium; Synthesis, Characterization, and Electrochemical Measurements
| dc.authorid | Alpaslan, Duygu/0000-0002-6007-3397 | |
| dc.authorid | Kivrak, Hilal/0000-0001-8001-7854 | |
| dc.authorid | Er, Omer Faruk/0000-0002-7179-726X | |
| dc.authorscopusid | 57195395441 | |
| dc.authorscopusid | 6506945988 | |
| dc.authorscopusid | 56721371400 | |
| dc.authorscopusid | 35434412700 | |
| dc.authorscopusid | 25959155500 | |
| dc.authorwosid | Er, Ömer Faruk/Aaj-6972-2021 | |
| dc.authorwosid | Aktas, Nahit/Glr-4607-2022 | |
| dc.authorwosid | Ersen Dudu, Tuba/Aab-5741-2022 | |
| dc.authorwosid | Kivrak, Hilal/Hji-7095-2023 | |
| dc.authorwosid | Alpaslan, Duygu/L-2759-2018 | |
| dc.authorwosid | Kivrak, Hilal/Aaq-8663-2021 | |
| dc.contributor.author | Er, Omer Faruk | |
| dc.contributor.author | Alpaslan, Duygu | |
| dc.contributor.author | Dudu, Tuba Ersen | |
| dc.contributor.author | Aktas, Nahit | |
| dc.contributor.author | Kivrak, Hilal | |
| dc.date.accessioned | 2025-05-10T17:21:02Z | |
| dc.date.available | 2025-05-10T17:21:02Z | |
| dc.date.issued | 2022 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Er, Omer Faruk; Alpaslan, Duygu; Dudu, Tuba Ersen] Van Yuzuncu Yil Univ, Fac Engn, Dept Chem Engn, TR-65000 Van, Turkey; [Aktas, Nahit] Kyrgyz Turkish Manas Univ, Fac Engn, Dept Chem Engn, Bishkek, Kyrgyzstan; [Kivrak, Hilal] Eskisehir Osmangazi Univ, Fac Engn & Architectural Sci, Dept Chem Engn, TR-26040 Eskisehir, Turkey; [Kivrak, Hilal] Eskisehir Osmangazi Univ, Translat Med Res & Clin Ctr, TR-26040 Eskisehir, Turkey | en_US |
| dc.description | Alpaslan, Duygu/0000-0002-6007-3397; Kivrak, Hilal/0000-0001-8001-7854; Er, Omer Faruk/0000-0002-7179-726X | en_US |
| dc.description.abstract | In present study, cacao oil-based organo-hydrogels (OHCOs) are synthesized to detect carcinoma antigen 125 (CA-125) in serum medium with electrochemical methods such as cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). OHCOs are prepared by the free radical polymerization reaction with agar, glycerol, and distinct ratios of cacao oil with glutaraldehyde (GA) crosslinker or methylene bisacrylamide (MBA) crosslinker. OHCOs are characterized via Fourier Transform Infrared Spec-troscopy (FT-IR), in different solvent environments and pHs. Electrochemical measurements are performed on OHCOs at the presence and absence of CA-125 antigen in serum medium. For the electrochemical sensor, two distinct linear ranges are determined as 0.00083-41.5 U/mL and 83.0-2075 U/mL. LOD and LOQ values are found as 0.34 mu U/mL and 1.01 mu U/mL, respectively. These results clearly show that OHCOs is a promising sensor material for the determination of CA-125 in human serum, sensitively. | en_US |
| dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK); Council of Higher Education (YOK); [2211-A]; [100/2000] | en_US |
| dc.description.sponsorship | O. F. ER thank the Scientific and Technological Research Council of Turkey (TUBITAK) for the 2211-A scholarship and the Council of Higher Education (YOK) for 100/2000 scholarship. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.1016/j.matchemphys.2022.126795 | |
| dc.identifier.issn | 0254-0584 | |
| dc.identifier.issn | 1879-3312 | |
| dc.identifier.scopus | 2-s2.0-85139354994 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https://doi.org/10.1016/j.matchemphys.2022.126795 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/10286 | |
| dc.identifier.volume | 292 | en_US |
| dc.identifier.wos | WOS:000869095800003 | |
| dc.identifier.wosquality | Q2 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Science Sa | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Ovarian Cancer | en_US |
| dc.subject | Ca-125 | en_US |
| dc.subject | Cacao Oil | en_US |
| dc.subject | Electrochemical | en_US |
| dc.subject | Sensor | en_US |
| dc.title | Novel Cacao Oil-Based Organo-Hydrogels To Detect Carcinoma Antigen 125 in Serum Medium; Synthesis, Characterization, and Electrochemical Measurements | en_US |
| dc.type | Article | en_US |