Preparation of Cerium Oxide-Mwcnts Nanocomposite Bulk Modified Carbon Ceramic Electrode: a Sensitive Sensor for Tamoxifen Determination in Human Serum Samples

Abstract

In this study, cerium oxide and multi-walled carbon nanotubes nanocomposite were incorporated into the carbon ceramic electrode (CeO2-MWCNTs/CCE) as a renewable electrode for the electrocatalytic purposes. To demonstrate capability of the fabricated electrode, determination of tamoxifen as an important anticancer drug with differential pulse voltammetry technique was evaluated in details. Linear range, limit of detection and sensitivity of the developed sensor were found to be 0.2-40 nM, 0.132 nM and 1.478 mu A nM(-1) cm(-2), respectively. Ease of production, low cost and high electron transfer rate of the CeO2-MWCNTs/CCE promises it as a novel electro-analytical tool for determination of important species in real samples.