Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats

Abstract

Liver diseases, morbidity and mortality rates are increasing in the world and existing drugs are insufficient for treatment. For this reason, there has been an increased interest in the discovery of new drugs against liver damage and the search for alternative therapies. This study investigated the cytoprotective and antioxidant effects of Allium schoenoprasum (AS) extract against carbon tetrachloride (CCl4) toxicity in rats. The in vivo experimental procedure was established as follows; Group 1, control (C) animals; Group 2, carboxymethylcellulose ( CMC); Group 3, CCl4; Group 4, Legalon (LGL, silymarin); Groups 5, 6 and 7 were treated with AS (100, 200 and 400 mg kg-1) extract only. Groups 8,9 and 10 were administered AS+CCl4. On the 11th day of the experiment, the animals were sacrificed and analyzed . According to the histopathological and biochemical analysis results; It was found that AS extract reduced tissue damage in a dose-dependent manner against CCl4 toxicity. When antioxidant and oxidative biomarkers were examined, positive effects of LGL and AS were observed in correcting the changed oxidant/antioxidant balance status due to oxidative stress caused by CCl4. The results showed that AS had a dose-dependent hepatoprotective effect against CCl4-induced liver toxicity and it was evaluated that thi s effect might be due to its antioxidant activity. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.