YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.
 

Nanoparticle Formation Capacity and Acaricidal Effect (Hyalomma Marginatum) of Essential Oil of Thymbra Spicata L. Subsp. Spicata L

dc.authorscopusid 58431071600
dc.authorscopusid 57194466973
dc.authorscopusid 55192425800
dc.authorscopusid 57211377356
dc.authorscopusid 57193432343
dc.authorscopusid 56210396000
dc.authorscopusid 56210396000
dc.authorwosid Toksoy, Mahmut Ozan/Abf-9745-2021
dc.authorwosid Uğurlu, Pelin/O-9562-2015
dc.contributor.author Kaya, Eda Cavus
dc.contributor.author Akdeniz, Mehmet
dc.contributor.author Ugurlu, Pelin
dc.contributor.author Yigitkan, Serkan
dc.contributor.author Toksoy, Mahmut Ozan
dc.contributor.author Firat, Mehmet
dc.contributor.author Ertas, Abdulselam
dc.date.accessioned 2025-05-10T17:29:26Z
dc.date.available 2025-05-10T17:29:26Z
dc.date.issued 2025
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Kaya, Eda Cavus] Dicle Univ, Fac Sci, Dept Inorgan Chem, TR-21280 Diyarbakir, Turkiye; [Akdeniz, Mehmet] Council Forens Med, Diyarbakir Grp Chairmanship, TR-21070 Diyarbakir, Turkiye; [Ugurlu, Pelin] Dicle Univ, Fac Pharm, Dept Basic Pharmaceut Sci, TR-21280 Diyarbakir, Turkiye; [Yigitkan, Serkan] Dicle Univ, Fac Pharm, Dept Pharmacognosy, TR-21280 Diyarbakir, Turkiye; [Toksoy, Mahmut Ozan] Dicle Univ, Fac Pharm, Dept Pharmaceut Technol, TR-21280 Diyarbakir, Turkiye; [Firat, Mehmet] Van Yuzuncu Yil Univ, Fac Educ, Dept Biol, TR-65080 Van, Turkiye; [Ertas, Abdulselam] Dicle Univ, Fac Pharm, Dept Analyt Chem, TR-21280 Diyarbakir, Turkiye en_US
dc.description.abstract The essential oil profile of Thymbra spicata L. subsp. spicata L. (Lamiaceae) was analyzed in this study using gas chromatography/mass spectrometry (GC-MS). Additionally, antioxidant and cytotoxic activities, along with inhibition activities for acetylcholinesterase, butyrylcholinesterase, urease, tyrosinase, elastase, collagenase, and angiotensin-converting enzymes, were assessed. Additionally, the acaricidal effects of the essential oil with strong antioxidant properties from T. spicata subsp. spicata, as well as the AgNO3 nanoparticles synthesized using this oil, were evaluated on Hyalomma marginatum nymphs. The main compounds present in the essential oil was identified as carvacrol (71.19%). The species exhibited remarkably high antioxidant activity, particularly in the ABTS cation radical scavenging activity and CUPRAC copper reducing capacity assays, with IC50 and A0.5 values of 1.80 +/- 0.053 and 1.30 +/- 0.12 mu g/mL, respectively. Additionally, the sample exhibited significantly high acetylcholinesterase and butyrylcholinesterase enzyme inhibition activities, with inhibition rates of 76.09 +/- 1.63% and 97.94 +/- 0.71%, respectively. It was also determined that the essential oil had moderate antimicrobial activity against the bacteria, and MIC values varied between 312 mu g/mL and 1250 mu g/mL. At the end of 24 hours, The LC50 values of essenttial oil and silver nanoparticles were determined to be 18.48 and 36.30 mu g/mL, respectively. The results of this study indicate that T. spicata may find application in dietary supplements due to its high carvacrol content and strong antioxidant, anticholinesterase, and acaricidal activities. en_US
dc.description.sponsorship Dicle University [ECZACILIK.18.002] en_US
dc.description.sponsorship This study was funded by Dicle University. Project number: ECZACILIK.18.002. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1080/0972060X.2025.2477711
dc.identifier.issn 0972-060X
dc.identifier.issn 0976-5026
dc.identifier.scopus 2-s2.0-105002085175
dc.identifier.scopusquality Q3
dc.identifier.uri https://doi.org/10.1080/0972060X.2025.2477711
dc.identifier.uri https://hdl.handle.net/20.500.14720/12344
dc.identifier.wos WOS:001455536700001
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Taylor & Francis Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Thymbra en_US
dc.subject Carvacrol en_US
dc.subject Gamma-Terpinene en_US
dc.subject Acaricidal Effect en_US
dc.subject Silver Nanoparticle en_US
dc.title Nanoparticle Formation Capacity and Acaricidal Effect (Hyalomma Marginatum) of Essential Oil of Thymbra Spicata L. Subsp. Spicata L en_US
dc.type Article en_US

Files