Nanoparticle Formation Capacity and Acaricidal Effect (Hyalomma Marginatum) of Essential Oil of Thymbra Spicata L. Subsp. Spicata L
dc.authorscopusid | 58431071600 | |
dc.authorscopusid | 57194466973 | |
dc.authorscopusid | 55192425800 | |
dc.authorscopusid | 57211377356 | |
dc.authorscopusid | 57193432343 | |
dc.authorscopusid | 56210396000 | |
dc.authorscopusid | 56210396000 | |
dc.authorwosid | Toksoy, Mahmut Ozan/Abf-9745-2021 | |
dc.authorwosid | Uğurlu, Pelin/O-9562-2015 | |
dc.contributor.author | Kaya, Eda Cavus | |
dc.contributor.author | Akdeniz, Mehmet | |
dc.contributor.author | Ugurlu, Pelin | |
dc.contributor.author | Yigitkan, Serkan | |
dc.contributor.author | Toksoy, Mahmut Ozan | |
dc.contributor.author | Firat, Mehmet | |
dc.contributor.author | Ertas, Abdulselam | |
dc.date.accessioned | 2025-05-10T17:29:26Z | |
dc.date.available | 2025-05-10T17:29:26Z | |
dc.date.issued | 2025 | |
dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
dc.department-temp | [Kaya, Eda Cavus] Dicle Univ, Fac Sci, Dept Inorgan Chem, TR-21280 Diyarbakir, Turkiye; [Akdeniz, Mehmet] Council Forens Med, Diyarbakir Grp Chairmanship, TR-21070 Diyarbakir, Turkiye; [Ugurlu, Pelin] Dicle Univ, Fac Pharm, Dept Basic Pharmaceut Sci, TR-21280 Diyarbakir, Turkiye; [Yigitkan, Serkan] Dicle Univ, Fac Pharm, Dept Pharmacognosy, TR-21280 Diyarbakir, Turkiye; [Toksoy, Mahmut Ozan] Dicle Univ, Fac Pharm, Dept Pharmaceut Technol, TR-21280 Diyarbakir, Turkiye; [Firat, Mehmet] Van Yuzuncu Yil Univ, Fac Educ, Dept Biol, TR-65080 Van, Turkiye; [Ertas, Abdulselam] Dicle Univ, Fac Pharm, Dept Analyt Chem, TR-21280 Diyarbakir, Turkiye | en_US |
dc.description.abstract | The essential oil profile of Thymbra spicata L. subsp. spicata L. (Lamiaceae) was analyzed in this study using gas chromatography/mass spectrometry (GC-MS). Additionally, antioxidant and cytotoxic activities, along with inhibition activities for acetylcholinesterase, butyrylcholinesterase, urease, tyrosinase, elastase, collagenase, and angiotensin-converting enzymes, were assessed. Additionally, the acaricidal effects of the essential oil with strong antioxidant properties from T. spicata subsp. spicata, as well as the AgNO3 nanoparticles synthesized using this oil, were evaluated on Hyalomma marginatum nymphs. The main compounds present in the essential oil was identified as carvacrol (71.19%). The species exhibited remarkably high antioxidant activity, particularly in the ABTS cation radical scavenging activity and CUPRAC copper reducing capacity assays, with IC50 and A0.5 values of 1.80 +/- 0.053 and 1.30 +/- 0.12 mu g/mL, respectively. Additionally, the sample exhibited significantly high acetylcholinesterase and butyrylcholinesterase enzyme inhibition activities, with inhibition rates of 76.09 +/- 1.63% and 97.94 +/- 0.71%, respectively. It was also determined that the essential oil had moderate antimicrobial activity against the bacteria, and MIC values varied between 312 mu g/mL and 1250 mu g/mL. At the end of 24 hours, The LC50 values of essenttial oil and silver nanoparticles were determined to be 18.48 and 36.30 mu g/mL, respectively. The results of this study indicate that T. spicata may find application in dietary supplements due to its high carvacrol content and strong antioxidant, anticholinesterase, and acaricidal activities. | en_US |
dc.description.sponsorship | Dicle University [ECZACILIK.18.002] | en_US |
dc.description.sponsorship | This study was funded by Dicle University. Project number: ECZACILIK.18.002. | en_US |
dc.description.woscitationindex | Science Citation Index Expanded | |
dc.identifier.doi | 10.1080/0972060X.2025.2477711 | |
dc.identifier.issn | 0972-060X | |
dc.identifier.issn | 0976-5026 | |
dc.identifier.scopus | 2-s2.0-105002085175 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.uri | https://doi.org/10.1080/0972060X.2025.2477711 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14720/12344 | |
dc.identifier.wos | WOS:001455536700001 | |
dc.identifier.wosquality | Q2 | |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Thymbra | en_US |
dc.subject | Carvacrol | en_US |
dc.subject | Gamma-Terpinene | en_US |
dc.subject | Acaricidal Effect | en_US |
dc.subject | Silver Nanoparticle | en_US |
dc.title | Nanoparticle Formation Capacity and Acaricidal Effect (Hyalomma Marginatum) of Essential Oil of Thymbra Spicata L. Subsp. Spicata L | en_US |
dc.type | Article | en_US |