The Association of Visfatin Levels With Metabolic Parameters and Inflammation in Diabetic Nephropathy
dc.authorscopusid | 57215867549 | |
dc.authorscopusid | 56890545900 | |
dc.authorscopusid | 55948548100 | |
dc.authorscopusid | 35786697700 | |
dc.authorscopusid | 35113230500 | |
dc.authorscopusid | 55293011200 | |
dc.authorscopusid | 55293011200 | |
dc.contributor.author | Sakin, A. | |
dc.contributor.author | Sahin, S. | |
dc.contributor.author | Behlul, A. | |
dc.contributor.author | Sumnu, A. | |
dc.contributor.author | Gursu, M. | |
dc.contributor.author | Sakin, A. | |
dc.contributor.author | Ozturk, S. | |
dc.date.accessioned | 2025-05-10T17:02:13Z | |
dc.date.available | 2025-05-10T17:02:13Z | |
dc.date.issued | 2020 | |
dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
dc.department-temp | Sakin A., University of Health Sciences, Department of Internal Medicine, Van Training and Research hospital, Van, Turkey; Sahin S., University of Health Sciences, Department of Internal Medicine, Van Training and Research hospital, Van, Turkey; Behlul A., University of Health Sciences, Department of Nephrology, Haseki Training and Research hospital, Van, Turkey; Sumnu A., University of Health Sciences, Department of Nephrology, Haseki Training and Research hospital, Van, Turkey; Gursu M., Department of Nephrology, Bezmialem University Faculty of Medicine, Istanbul, Turkey; Sakin A., Department of Internal Medicine, Yuzuncu Yil University Medical School, Van, 65030, Turkey; Ozturk S., University of Health Sciences, Department of Nephrology, Haseki Training and Research hospital, Van, Turkey | en_US |
dc.description.abstract | To investigate the visfatin levels at the stages of diabetic nephropathy(DNP), changes in visfatin levels according to stages of DNP, and the association of visfatin levels with other anti-inflammatory parameters including high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and tumor necrosis factor alpha(TNFα). Patients were divided into 4 groups based on the glomerular filtration rate (GFR) and albuminuria as follows; Group I: Albuminuria<30 mg per day and GFR>60ml/min, Group II:albuminuria 30 to 300 mg per day and GFR>60ml/min, Group III:albuminuria>300mg per day and GFR>60ml/min, and Group IV: Albuminuria>300 mg per day and GFR<60 ml/min. Of the 141 patients included in the study, 83(58.8%) were female. The mean age of patients was 55.3±8.2 years. Microalbuminuria was found to be 10.1±9.8 mg per day in group I, 89.4±68.2 mg per day in group II, 525.1±280.7 mg per day in group III, and 1034±1893 mg per day in group IV (p<0.001). When the correlation analysis was repeated separately in each group, there was a positive correlation between Visfatin and IL-6 levels in only group III (r=0.926; p<0.001). When the patients in group III and IV were combined in a single group and considered as macro-albuminuric, multivariate analysis showed that visfatin had a positive correlation with IL-6 (r=0.380, p=0.006) In this study, we could not determine any association between visfatin levels and other anti-inflammatory markers (IL-6, TNFα, and hsCRP). However, we found a close relationship between visfatin levels and IL-6 which is one of the most important markers of inflammation in diabetic patients with overt nephropathy, namely macro-albuminuric patients. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved. | en_US |
dc.identifier.doi | 10.5505/ejm.2020.27122 | |
dc.identifier.endpage | 224 | en_US |
dc.identifier.issn | 1301-0883 | |
dc.identifier.issue | 2 | en_US |
dc.identifier.scopus | 2-s2.0-85083674831 | |
dc.identifier.scopusquality | Q4 | |
dc.identifier.startpage | 218 | en_US |
dc.identifier.trdizinid | 361646 | |
dc.identifier.uri | https://doi.org/10.5505/ejm.2020.27122 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14720/5448 | |
dc.identifier.volume | 25 | en_US |
dc.identifier.wosquality | N/A | |
dc.language.iso | en | en_US |
dc.publisher | Yuzuncu Yil Universitesi Tip Fakultesi | en_US |
dc.relation.ispartof | Eastern Journal of Medicine | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Diabetes Mellitus | en_US |
dc.subject | Diabetic Nephropathy | en_US |
dc.subject | Inflammation Marker | en_US |
dc.subject | Visfatin | en_US |
dc.title | The Association of Visfatin Levels With Metabolic Parameters and Inflammation in Diabetic Nephropathy | en_US |
dc.type | Article | en_US |