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The Association of Visfatin Levels With Metabolic Parameters and Inflammation in Diabetic Nephropathy

dc.authorscopusid 57215867549
dc.authorscopusid 56890545900
dc.authorscopusid 55948548100
dc.authorscopusid 35786697700
dc.authorscopusid 35113230500
dc.authorscopusid 55293011200
dc.authorscopusid 55293011200
dc.contributor.author Sakin, A.
dc.contributor.author Sahin, S.
dc.contributor.author Behlul, A.
dc.contributor.author Sumnu, A.
dc.contributor.author Gursu, M.
dc.contributor.author Sakin, A.
dc.contributor.author Ozturk, S.
dc.date.accessioned 2025-05-10T17:02:13Z
dc.date.available 2025-05-10T17:02:13Z
dc.date.issued 2020
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Sakin A., University of Health Sciences, Department of Internal Medicine, Van Training and Research hospital, Van, Turkey; Sahin S., University of Health Sciences, Department of Internal Medicine, Van Training and Research hospital, Van, Turkey; Behlul A., University of Health Sciences, Department of Nephrology, Haseki Training and Research hospital, Van, Turkey; Sumnu A., University of Health Sciences, Department of Nephrology, Haseki Training and Research hospital, Van, Turkey; Gursu M., Department of Nephrology, Bezmialem University Faculty of Medicine, Istanbul, Turkey; Sakin A., Department of Internal Medicine, Yuzuncu Yil University Medical School, Van, 65030, Turkey; Ozturk S., University of Health Sciences, Department of Nephrology, Haseki Training and Research hospital, Van, Turkey en_US
dc.description.abstract To investigate the visfatin levels at the stages of diabetic nephropathy(DNP), changes in visfatin levels according to stages of DNP, and the association of visfatin levels with other anti-inflammatory parameters including high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and tumor necrosis factor alpha(TNFα). Patients were divided into 4 groups based on the glomerular filtration rate (GFR) and albuminuria as follows; Group I: Albuminuria<30 mg per day and GFR>60ml/min, Group II:albuminuria 30 to 300 mg per day and GFR>60ml/min, Group III:albuminuria>300mg per day and GFR>60ml/min, and Group IV: Albuminuria>300 mg per day and GFR<60 ml/min. Of the 141 patients included in the study, 83(58.8%) were female. The mean age of patients was 55.3±8.2 years. Microalbuminuria was found to be 10.1±9.8 mg per day in group I, 89.4±68.2 mg per day in group II, 525.1±280.7 mg per day in group III, and 1034±1893 mg per day in group IV (p<0.001). When the correlation analysis was repeated separately in each group, there was a positive correlation between Visfatin and IL-6 levels in only group III (r=0.926; p<0.001). When the patients in group III and IV were combined in a single group and considered as macro-albuminuric, multivariate analysis showed that visfatin had a positive correlation with IL-6 (r=0.380, p=0.006) In this study, we could not determine any association between visfatin levels and other anti-inflammatory markers (IL-6, TNFα, and hsCRP). However, we found a close relationship between visfatin levels and IL-6 which is one of the most important markers of inflammation in diabetic patients with overt nephropathy, namely macro-albuminuric patients. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved. en_US
dc.identifier.doi 10.5505/ejm.2020.27122
dc.identifier.endpage 224 en_US
dc.identifier.issn 1301-0883
dc.identifier.issue 2 en_US
dc.identifier.scopus 2-s2.0-85083674831
dc.identifier.scopusquality Q4
dc.identifier.startpage 218 en_US
dc.identifier.trdizinid 361646
dc.identifier.uri https://doi.org/10.5505/ejm.2020.27122
dc.identifier.uri https://hdl.handle.net/20.500.14720/5448
dc.identifier.volume 25 en_US
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Yuzuncu Yil Universitesi Tip Fakultesi en_US
dc.relation.ispartof Eastern Journal of Medicine en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Diabetes Mellitus en_US
dc.subject Diabetic Nephropathy en_US
dc.subject Inflammation Marker en_US
dc.subject Visfatin en_US
dc.title The Association of Visfatin Levels With Metabolic Parameters and Inflammation in Diabetic Nephropathy en_US
dc.type Article en_US

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