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PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14720/6

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Browsing PubMed İndeksli Yayınlar Koleksiyonu by Author "Abdelmegid, Shaimaa"

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    An Evaluation of the Lineage of Brucella Isolates in Turkey by a Whole-Genome Single-Nucleotide Polymorphism Analysis
    (Mdpi, 2024) Akar, Kadir; Holzer, Katharina; Hoelzle, Ludwig E.; Oz, Gulseren Yildiz; Abdelmegid, Shaimaa; Baklan, Emin Ayhan; Elkhayat, Manar
    Brucellosis is a disease that is commonly found in Turkey among both humans and animals. It causes significant economic losses in the livestock industry and is of great public health concern. This study focused on analyzing the genetic makeup of Brucella isolates from Turkey using a core-genome single-nucleotide polymorphism (cgSNP) analysis. This analysis showed potential links between the Turkish isolates and those from neighboring countries and other parts of the world. This highlights the importance of implementing strict measures to control the spread of brucellosis throughout the country. Brucellosis is a disease caused by the Brucella (B.) species. It is a zoonotic disease that affects farm animals and causes economic losses in many countries worldwide. Brucella has the ability to persist in the environment and infect the host at low doses. Thus, it is more important to trace brucellosis outbreaks, identify their sources of infection, and interrupt their transmission. Some countries already have initial data, but most of these data are based on a Multiple-Locus Variable-Number Tandem-Repeat Analysis (MLVA), which is completely unsuitable for studying the Brucella genome. Since brucellosis is an endemic disease in Turkey, this study aimed to examine the genome of Turkish Brucella isolates collected between 2018 and 2020, except for one isolate, which was from 2012. A total of 28 strains of B. melitensis (n = 15) and B. abortus (n = 13) were analyzed using a core-genome single-nucleotide polymorphism (cgSNP) analysis. A potential connection between the Turkish isolates and entries from Sweden, Israel, Syria, Austria, and India for B. melitensis was detected. For B. abortus, there may be potential associations with entries from China. This explains the tight ties found between Brucella strains from neighboring countries and isolates from Turkey. Therefore, it is recommended that strict measures be taken and the possible effects of uncontrolled animal introduction are emphasized.