PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14720/6

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Browsing PubMed İndeksli Yayınlar Koleksiyonu by Publisher "Academic Press Inc Elsevier Science"

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    Article
    Strategic Engineering of Imidazopyridine-Benzoxazole Hybrids Targeting Microtubule Dynamics: Comprehensive Inhibition of the Metastatic Cascade
    (Academic Press Inc Elsevier Science, 2026) Kuzu, Burak; Cakir, Mustafa; Acikgoz, Eda
    A series of twenty novel imidazopyridine-benzoxazole hybrid (Imp1-20) derivatives was designed and synthesized, and their antiproliferative activities were evaluated against MDA-MB-231 breast and DLD-1 colorectal cancer cell lines. Among them, Imp-18 and Imp-20 emerged as the most potent candidates, with low micromolar to nanomolar IC50 values and significant reductions in cancer cell adhesion and colony formation. Flow cytometry analyses demonstrated that both compounds induced apoptosis and promoted cell-cycle arrest, reflected by Sub-G1 accumulation and perturbations in G1/G0 and G2/M phases. Immunofluorescence imaging of beta-tubulin confirmed that Imp-18 and Imp-20 compromise microtubule integrity, with Imp-18 displaying stronger tubulin-disrupting activity than nocodazole. The resulting microtubule destabilization was consistent with mitotic arrest and activation of apoptotic signaling pathways. Additionally, both compounds markedly inhibited cancer cell migration, indicating an ability to impair metastatic behavior. Overall, these findings identify Imp-18 and Imp-20 as promising microtubule-targeting agents with robust anticancer potential, providing a strong basis for further mechanistic studies and structural optimization within the framework of medicinal and bioorganic chemistry.
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    Syringic Acid Mitigates Scopolamine-Induced Cognitive Impairment by Regulating PSD-95 and GSK-3β and by Preventing Neurodegeneration in an Alzheimer-Like Rat Model
    (Academic Press Inc Elsevier Science, 2026) Altindag, Fikret; Bayir, Mehmet Hafit; Alhalboosi, Jamal Khalid Ismael; Yildizhan, Kenan
    Alzheimer's disease (AD) is a disorder characterized by progressive cognitive impairment. Syringic acid (SA) is a phenolic compound with many beneficial effects, such as antioxidant, anti-inflammatory, anti-diabetic, anticarcinogenic, and neuroprotective. Our study aimed to investigate the effects of SA (50 mg/kg/day) on scopolamine (SCO)-induced AD-like condition in rats. Immunohistochemical evaluation was performed using antibodies to postsynaptic density protein 95 (PSD-95), Glycogen synthase kinase-3 beta (GSK-3 beta), TNF-alpha, and caspase-3. The hippocampus was stained with Hematoxylin-Eosin, and the total number of hippocampal neurons and hippocampal volume were calculated using the stereological method. The Y-maze task behavioral test was performed. SCO decreased PSD-95 expression while increasing GSK-3 beta, TNF-alpha, and caspase-3 expression. SA treatment increased PSD-95 expression while decreasing GSK-3 beta, TNF-alpha, and caspase-3 expression. Compared to the control group, the number of hippocampal neurons was significantly decreased in the Alzheimer's group, but the number of neurons in the SA group was significantly higher than in the Alzheimer's group. Hippocampal volume was lower in the Alzheimer's group, although there was no statistical difference between the groups. SA also improved SCO-induced cognitive impairment. Our study findings suggest that SA may mitigate SCO-induced cognitive impairment in the AD rat model, modulating PSD-95 and GSK-3 beta and decreasing neuroinflammation and apoptosis.