PubMed İndeksli Yayınlar Koleksiyonu

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Browsing PubMed İndeksli Yayınlar Koleksiyonu by Publisher "Acta dermato-venereologica"

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    Article
    Insulin Resistance Is Increased in Patients With Vitiligo
    (Acta dermato-venereologica, 2011) Karadag, Ayse Serap; Tutal, Emre; Ertugrul, Derun Taner
    The aim of this study was to evaluate the relationship between vitiligo and insulin resistance (IR). A total of 96 subjects were included in the study; 57 patients with vitiligo and 39 subjects in an age and a body mass index-matched control group. In fasting blood samples, insulin, C-peptide, glucose, total cholesterol, triglyceride, low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) were measured. IR was calculated with the homeostasis model assessment-IR (HOMA-IR) method. Comparison of the vitiligo and the control groups revealed that patients with vitiligo had higher IR (2.3 vs. 2.0,p<0.01), higher insulin and C-peptide levels (p<0.001, p<0.001, respectively), higher LDL/HDL ratio and lower HDL-C levels (p<0.01, p<0.0001, respectively). Systolic blood pressures of patients with vitiligo were also higher compared with control subjects (p<0.01). Further experimental and clinical studies are needed to elucidate the molecular mechanisms underlying this association.
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    Article
    Isotretinoin Influences Pituitary Hormone Levels in Acne Patients
    (Acta dermato-venereologica, 2011) Karadag, Ayse Serap; Ertugrul, Derun Taner; Tutal, Emre; Akin, Kadir Okhan
    Besides suppressing sebum production, the exact mechanism of action of isotretinoin in acne vulgaris is not known. Several hormones have been linked to the pathogenesis of acne. In this study, we investigated the effects of isotretinoin on the pituitary-adrenal axis, whose activity may be increased in acne. Various hormone systems were evaluated before and after 3 months of isotretinoin treatment in 47 acne patients. Free triiodothyronine (T3), thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibody levels decreased significantly during isotretinoin treatment (p<0.001, p<0.02 and p<0.02, respectively), as did those of luteinising hormone, prolactin and total testosterone (p<0.005), as well as morning cortisol and adrenocorticotropic hormone (p<0.005 and p<0.05, respectively). We conclude that isotretinoin causes mild suppression of pituitary hormone levels, which may be beneficial for tackling the pathogenesis of acne.