Probing the DNA Interaction Behavior of Tetrakis (Benzhydryloxy Phthalocyaninato) Mg (II) Complex

Abstract

In this work, we evaluated the DNA interaction behaviors of previously prepared and characterized peripherally tetra-substituted Mg(II) phthalocyanine containing a tetrakis (benzhydryloxy) group. The 2, 10, 16, 24-tetrakis (benzhydryloxy phthalocyaninato) Mg(II) complex was studied is soluble in organic solvents. During the synthesis and characterization phase, absorption spectroscopy, infrared spectroscopy and 1H NMR were utilized to elucidate the chemical structure of the MgPc complex. For this complex, DNA binding behaviours were investigated with various techniques like electronic absorption spectroscopy, fluorescence emission spectra, electrophoresis and thermal denaturation. To reveal the binding pattern of the MgPc complex to DNA, the binding constant was calculated and found to be 1.73 x 10(6) M-1 for the complex. All the results obtained from the techniques applied showed that MgPc tends to interact with the DNA molecule and confirmed that this interaction occurs intercalatively.