Anti-Inflammatory Effects of Usnic Acid in Breast Cancer
| dc.contributor.author | Yildirim, M. | |
| dc.contributor.author | Degirmenci, U. | |
| dc.contributor.author | Akkapulu, M. | |
| dc.contributor.author | Gungor, M. | |
| dc.contributor.author | Oztornaci, R. O. | |
| dc.contributor.author | Berkoz, M. | |
| dc.contributor.author | Yalin, S. | |
| dc.date.accessioned | 2025-05-10T17:20:16Z | |
| dc.date.available | 2025-05-10T17:20:16Z | |
| dc.date.issued | 2022 | |
| dc.description | Oztornaci, Ragip Onur/0000-0002-9847-4030; Comelekoglu, Ulku/0000-0001-8060-6333 | en_US |
| dc.description.abstract | cancer is the most common type of cancer among women. Usnic acid has anticancer and anti-inflammatory potential. In this study, we evaluated the effects of usnic acid on inflammation and oxidative stress in the breast cancer cell line (MCF-7). Cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) gene expression, cytokines, nitric oxide (NO), prostaglandin E2 (PGE2) levels and oxidative stress were measured in all groups. Our study showed that usnic acid was decreased NO, VEGF, PGE2 levels, gene expression levels of COX-2 and iNOS in the meantime cytokines (IL 2, CXCL 10, CXCL8, CCL2 (MCP-1), TNF-alpha, IL-6), glutathione levels, moreover decreased GSH and increased MDA levels in dose depended manner. According to our evidence usnic acid was showed potential cytotoxic, anti-inflammatory and pro oxidant role. | en_US |
| dc.description.sponsorship | Scientific Research Committee of Mersin University [2018-2-TP3-2957] | en_US |
| dc.description.sponsorship | The research leading to these results received funding from Scientific Research Committee of Mersin University under Grant Agreement no. 2018-2-TP3-2957. | en_US |
| dc.identifier.doi | 10.1134/S1068162023010296 | |
| dc.identifier.issn | 1068-1620 | |
| dc.identifier.issn | 1608-330X | |
| dc.identifier.scopus | 2-s2.0-85144696306 | |
| dc.identifier.uri | https://doi.org/10.1134/S1068162023010296 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/10036 | |
| dc.language.iso | en | en_US |
| dc.publisher | Maik Nauka/interperiodica/springer | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Usnic Acid | en_US |
| dc.subject | Breast Cancer | en_US |
| dc.subject | Anti-Inflammatory | en_US |
| dc.subject | Mcf-7 | en_US |
| dc.subject | Oxidative Stress | en_US |
| dc.title | Anti-Inflammatory Effects of Usnic Acid in Breast Cancer | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Oztornaci, Ragip Onur/0000-0002-9847-4030 | |
| gdc.author.id | Comelekoglu, Ulku/0000-0001-8060-6333 | |
| gdc.author.scopusid | 57193389683 | |
| gdc.author.scopusid | 9635916400 | |
| gdc.author.scopusid | 57194420035 | |
| gdc.author.scopusid | 55509216200 | |
| gdc.author.scopusid | 57218676130 | |
| gdc.author.scopusid | 12801030200 | |
| gdc.author.scopusid | 56509249400 | |
| gdc.author.wosid | Yalın, Serap/L-7402-2017 | |
| gdc.author.wosid | Deği̇rmenci̇, Ulaş/Abc-2461-2021 | |
| gdc.author.wosid | Yldrm, Mtn/Jmp-9922-2023 | |
| gdc.author.wosid | Öztornacı, Onur/Iyi-8400-2023 | |
| gdc.author.wosid | Comelekoglu, Ulku/E-2239-2016 | |
| gdc.coar.access | metadata only access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.description.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| gdc.description.departmenttemp | [Yildirim, M.; Akkapulu, M.; Yalin, A. E.; Yalin, S.] Mersin Univ, Fac Pharm, Dept Biochem, Mersin, Turkey; [Degirmenci, U.] Harran Univ, Fac Pharm, Dept Biochem, Sanliurfa, Turkey; [Gungor, M.] Sanko Univ, Fac Med, Dept Biochem, Gaziantep, Turkey; [Oztornaci, R. O.] Mersin Univ, Fac Med, Dept Biostat, Mersin, Turkey; [Berkoz, M.] Van Yuzunci Yil Univ, Fac Pharm, Dept Biochem, Van, Turkey; [Comelekoglu, U.] Mersin Univ, Fac Med, Dept Biophys, Mersin, Turkey | en_US |
| gdc.description.endpage | S114 | en_US |
| gdc.description.issue | SUPPL 1 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q4 | |
| gdc.description.startpage | S110 | en_US |
| gdc.description.volume | 48 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.description.wosquality | N/A | |
| gdc.identifier.wos | WOS:000903128500004 | |
| gdc.index.type | WoS | |
| gdc.index.type | Scopus |