The Comparison of Resveratrol and N-Acetylcysteine on the Oxidative Kidney Damage Caused by High Dose Paracetamol

Abstract

In this study, the effects of resveratrol were investigated on paracetamol-induced oxidative kidney damage in rats and compared with N-acetylcysteine (NAC). Rats were divided into healthy (HG), paracetamol control (PAC), resveratrol + paracetamol (RPA), NAC + paracetamol (NPA) groups. RPA group was administered 30 mg/kg resveratrol, NPA group was administered NAC in 300 mg/kg doses. Distilled water was administered to HG and PAC group. One hour after administration of the drugs and distilled water, all groups (except for HG) were given paracetamol 1000 mg/kg dose. 24 h after paracetamol administration, animals were killed by anesthesia and their kidneys were removed. Biochemical investigations were carried out on the kidneys. Resveratrol and NAC almost equally suppressed the increase of malondialdehyde (MDA) amount in the renal tissue of paracetamol-administered group. But resveratrol reduced the increase of 8-hydroxyguanine (8-OHGua), creatinine and blood urea nitrogen (BUN) more significantly than NAC. Resveratrol prevented loss of total glutathione (tGSH) in rats taking paracetamol better than NAC. As a result, resveratrol was determined to prevent oxidative renal damage and functional disorder related to paracetamol better than NAC.