Synthesis, Optimization, Adme Analysis, and Antioxidant Activity of 2-(arylethynyl)
| dc.contributor.author | Kavak, E. | |
| dc.contributor.author | Algso, M. A. S. | |
| dc.contributor.author | Konus, M. | |
| dc.contributor.author | Yilmaz, C. | |
| dc.contributor.author | Lazoglu, A. | |
| dc.contributor.author | Karaagac, S. U. | |
| dc.contributor.author | Kivrak, A. | |
| dc.date.accessioned | 2025-05-10T17:07:59Z | |
| dc.date.available | 2025-05-10T17:07:59Z | |
| dc.date.issued | 2021 | |
| dc.description | Kavak, Emrah/0000-0002-6161-2030; Konus, Metin/0000-0002-9953-1375; Yilmaz, Can/0000-0002-0028-6614; Kivrak, Arif/0000-0003-4770-2686 | en_US |
| dc.description.abstract | 2,3-Dialkynylthiophene derivatives were synthesized by using regio- and stereocontrolled Pd-catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds were analyzed in silico for their pharmacokinetic parameters, general toxicity, and drug scores. In particular, 3-ethynyl-2-(phenylethynyl)thiophene and 3-ethynyl-2-[(4-methylphenyl)ethynyl]thiophene were found to have relatively high drug scores and low toxicities. The antioxidant activity of the title compounds were evaluated by five different assays. 3-Ethynyl-2-(naphthalen-1-ylethynyl)thiophene displayed significant reducing and free radical scavenging activities. | en_US |
| dc.description.sponsorship | Scientific and Technological Research Council of Turkey [114Z042]; Van Yuzuncu Yil University [FYL-2016-5243, FYL-2018-7439]; COST Action "Challenging Organic Syntheses Inspired by Nature from Natural Products Chemistry to Drug Discovery" [CM1407]; COST Action "New Diagnostic and Therapeutic Tools Against Multidrug Resistant Tumors" [CA17104] | en_US |
| dc.description.sponsorship | The authors thank The Scientific and Technological Research Council of Turkey (project no. 114Z042) for providing microwave reactor and chemicals and Van Yuzuncu Yil University (FYL-2016-5243; synthesis of compounds; FYL-2018-7439, financial support). A. Kivrak, C. Yilmaz, and M. Konus would like to acknowledge networking contribution by the COST Action CM1407 "Challenging Organic Syntheses Inspired by Nature from Natural Products Chemistry to Drug Discovery." A. Kivrak also would like to acknowledge networking contribution by the COST Action CA17104 "New Diagnostic and Therapeutic Tools Against Multidrug Resistant Tumors." | en_US |
| dc.identifier.doi | 10.1134/S1070428021010139 | |
| dc.identifier.issn | 1070-4280 | |
| dc.identifier.issn | 1608-3393 | |
| dc.identifier.scopus | 2-s2.0-85101779491 | |
| dc.identifier.uri | https://doi.org/10.1134/S1070428021010139 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/6933 | |
| dc.language.iso | en | en_US |
| dc.publisher | Maik Nauka/interperiodica/springer | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Thiophene | en_US |
| dc.subject | Coupling Reactions | en_US |
| dc.subject | Heteroaromatic Compounds | en_US |
| dc.subject | Adme | en_US |
| dc.subject | Antioxidants | en_US |
| dc.title | Synthesis, Optimization, Adme Analysis, and Antioxidant Activity of 2-(arylethynyl) | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Kavak, Emrah/0000-0002-6161-2030 | |
| gdc.author.id | Konus, Metin/0000-0002-9953-1375 | |
| gdc.author.id | Yilmaz, Can/0000-0002-0028-6614 | |
| gdc.author.id | Kivrak, Arif/0000-0003-4770-2686 | |
| gdc.author.scopusid | 56891345500 | |
| gdc.author.scopusid | 57203329350 | |
| gdc.author.scopusid | 56387553800 | |
| gdc.author.scopusid | 57221517895 | |
| gdc.author.scopusid | 58708055300 | |
| gdc.author.scopusid | 53880170900 | |
| gdc.author.scopusid | 53880170900 | |
| gdc.author.wosid | Kivrak, Arif/Aaq-8432-2021 | |
| gdc.author.wosid | Yilmaz, Can/Grs-2754-2022 | |
| gdc.author.wosid | Kavak, Emrah/Gls-1399-2022 | |
| gdc.author.wosid | Kivrak, Arif/W-2196-2017 | |
| gdc.coar.access | metadata only access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.description.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| gdc.description.departmenttemp | [Kavak, E.; Algso, M. A. S.; Kivrak, A.] Van Yuzuncu Yil Univ, Dept Chem, TR-65080 Van, Turkey; [Konus, M.; Yilmaz, C.; Lazoglu, A.] Van Yuzuncu Yil Univ, Dept Mol Biol & Genet, TR-65080 Van, Turkey; [Karaagac, S. U.] Karabuk Univ, Dept Environm Engn, TR-78050 Karabuk, Turkey; [Konus, M.] Hitit Univ, Dept Mol Biol & Genet, TR-19030 Corum, Turkey; [Kivrak, A.] Eskisehir Osmangazi Univ, Fac Sci & Arts, Dept Chem, TR-26040 Eskisehir, Turkey | en_US |
| gdc.description.endpage | 99 | en_US |
| gdc.description.issue | 1 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q4 | |
| gdc.description.startpage | 91 | en_US |
| gdc.description.volume | 57 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded - Index Chemicus | |
| gdc.description.wosquality | Q4 | |
| gdc.identifier.wos | WOS:000621823200013 | |
| gdc.index.type | WoS | |
| gdc.index.type | Scopus |