The Effect of Coq10 and Vitamin E on Serum Total Sialic Acid, Lipid-Bound Sialic Acid, Some Trace Elements and Minerals in Rats Induced With Doxorubicin

Abstract

This study was designed to evaluate the effect of CoQ(10) and vitamin E on serum total sialic acid (TSA), lipid bound sialic acid (LSA) and some elements in rat administered doxorubicin (DXR). Cu levels were increased in the group treated with DXR + vitamin E in comparison with DXR (p<0.05) and CoQ(10) groups (p = 0.001). Furthermore, copper levels were increased in the group treated with DXR + CoQ10 in comparison with CoQ(10) group (p < 0.05). Zn levels were decreased in the group treated with DXR + vitamin E in comparison with CoQ(10) group (p < 0.05). Mg levels were decreased in subjects treated with DXR + vitamin E in comparison with the control group values (p < 0.05). Particularly, the observed increase in Cu levels in rats from DXR + vitamin E group might be due to the decrease of vitamin E. However, the oxidative damage could be as a result of DXR occurence and may be helpful to clinicians in chemotherapy using anthracycline.