Examination of the Relationship Between Intermittent Fasting and Irisine Levels in Rats Fed a High-Fat Diet

Abstract

In this study, the relationship between intermittent fasting and irisin levels has been examined in rats fed on a high-fat diet. Eighteen Wistar albino rats were randomly divided into three groups as control, high-fat diet (HFD) and, high-fat diet+intermittent fasting (HFD+IF) (n=6). After 8 weeks of study irisin level were measured in serum. Irisin levels in the HFD group were lower (8.24 ng/ml) than the control (10.50 ng/ml) but in the HFD+IF group was higher (12.25 ng/ml) compared to the HFD group (8.24 ng/ml) (P<0.05). It was observed that body weight in the HFD group was higher (385.92 g) than the control group (270.50 g) and was lower (297.71 g) in the HFD+IF group compared to the HFD group (385.92 g) (P<0.05). As a result, it has been seen that intermittent fasting increases the level of irisin and causes weight loss, and it is conclu ded that it can be evaluated among the methods to be used in the treatment and prevention of obesity. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.