Voltammetric Analysis and Electrochemical Behavior of an Antibiotic Drug Nifuroxazide on a Boron-Doped Diamond Electrode in the Existence of a Cationic Surfactant

Abstract

In this work, the voltammetric sensing of nifuroxazide (NFX) was assessed utilizing a boron-doped diamond (BDD) electrode that underwent electrochemical pretreatment, enhancing its surface activity. Cyclic voltammograms of NFX revealed well-defined, single, and irreversible peaks at 0.94 V (vs. Ag/AgCl) in a 0.04 M Britton- Robinson (BR) buffer solution at pH 6.0. The oxidation peaks of NFX were found to be pH-dependent across a range from 2.0 to 12.0. Introducing a cationc surfactant (CTAB; cetyltrimethylammonium bromide) into the selected electrolyte increased the anodic peak currents of NFX. Under optimized conditions, a linear relationship was established for NFX quantification in 0.04 M solution of BR buffer (pH 6.0) containing 2×10-4 M CTAB at +1.02 V (vs. Ag/AgCl). The linear range spanned from 0.05 to 2.0 μg mL-1 (1.8×10-7 – 7.2×10-6 M), with a detection limit of 0.013 μg mL-1 (4.7×10-8 M). The NFX concentration in the drug formulation was successfully quantized using this method.