The Effects of Epinephrine, Norepinephrine and Dopamine on Hemogram and Coagulation Parameters
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Date
2025
Journal Title
Journal ISSN
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Publisher
Yuzuncu Yil Universitesi Tip Fakultesi
Abstract
Introduction: Vasopressor agents stimulate endothelial cells and platelets via the sympathetic nervous system and affect the coagulation cascade through various mediators. This study aimed to investigate the effects of epinephrine, norepinephrine, and dopamine on hemogram and coagulation parameters. Materials and Methods: A total of 28 healthy Wistar albino rats weighing 250-300 grams were used in this study. The rats were randomly divided into four groups, with 7 in each group. 0.9 % serum physiologic (group C, n=7), epinephrine (group E, n=7), norepinephrine (group NE, n= 7), dopamine (group D, n=7) were intraperitoneally perfused to the rats under sedation. Blood samples were draw n from the rats 30 minutes after perfusion. Hemogram and coagulation parameters were compared between the groups. Results: Granulocyte values were lower in the dopamine group. Platelet cluster count was higher in the dopamine group. The highest hemoglobin and hematocrit values measured among the groups were observed in Group E, and its values were higher than those in the norepinephrine and control groups. Conclusion: It has been determined that vasopressor drugs affect hemogram values and platelet aggregation in different ways, but do not cause any changes in coagulation parameters. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
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Keywords
Blood Coagulation Factors, Dopamine, Epinephrine, Hematocrit, Norepinephrine, Platelet Count
Turkish CoHE Thesis Center URL
WoS Q
N/A
Scopus Q
N/A
Source
Van Medical Journal
Volume
32
Issue
3
Start Page
158
End Page
163