The Effects of Epinephrine, Norepinephrine and Dopamine on Hemogram and Coagulation Parameters

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dc.authorscopusid 60011552600
dc.authorscopusid 36968242400
dc.authorscopusid 23488098800
dc.authorscopusid 36157712500
dc.authorscopusid 59331829900
dc.authorscopusid 57214594125
dc.contributor.author Tunçdemir, E.
dc.contributor.author Yüzkat, N.
dc.contributor.author Bayram, Y.
dc.contributor.author Başbuğan, Y.
dc.contributor.author Cintan, K.
dc.contributor.author Türk, Ö.
dc.date.accessioned 2025-09-03T16:40:09Z
dc.date.available 2025-09-03T16:40:09Z
dc.date.issued 2025
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Tunçdemir E.] The Ministry of Health, Van Training and Research Hospital, Department of Anesthesiology and Reanimation, Van, Turkey; [Yüzkat N.] Van Yuzuncu Yil University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Van, Turkey; [Bayram Y.] Van Yuzuncu Yil University, Faculty of Medicine, Department of Clinical Microbiology, Van, Turkey; [Başbuğan Y.] Van Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Internal Medicine, Van, Turkey; [Cintan K.] The Ministry of Health, Van Training and Research Hospital, Department of Anesthesiology and Reanimation, Van, Turkey; [Türk Ö.] The Ministry of Health, Van Training and Research Hospital, Department of Anesthesiology and Reanimation, Van, Turkey en_US
dc.description.abstract Introduction: Vasopressor agents stimulate endothelial cells and platelets via the sympathetic nervous system and affect the coagulation cascade through various mediators. This study aimed to investigate the effects of epinephrine, norepinephrine, and dopamine on hemogram and coagulation parameters. Materials and Methods: A total of 28 healthy Wistar albino rats weighing 250-300 grams were used in this study. The rats were randomly divided into four groups, with 7 in each group. 0.9 % serum physiologic (group C, n=7), epinephrine (group E, n=7), norepinephrine (group NE, n= 7), dopamine (group D, n=7) were intraperitoneally perfused to the rats under sedation. Blood samples were draw n from the rats 30 minutes after perfusion. Hemogram and coagulation parameters were compared between the groups. Results: Granulocyte values were lower in the dopamine group. Platelet cluster count was higher in the dopamine group. The highest hemoglobin and hematocrit values measured among the groups were observed in Group E, and its values were higher than those in the norepinephrine and control groups. Conclusion: It has been determined that vasopressor drugs affect hemogram values and platelet aggregation in different ways, but do not cause any changes in coagulation parameters. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved. en_US
dc.identifier.doi 10.5505/VMJ.2025.41713
dc.identifier.endpage 163 en_US
dc.identifier.issn 1300-2694
dc.identifier.issue 3 en_US
dc.identifier.scopus 2-s2.0-105011487812
dc.identifier.scopusquality N/A
dc.identifier.startpage 158 en_US
dc.identifier.uri https://doi.org/10.5505/VMJ.2025.41713
dc.identifier.uri https://hdl.handle.net/20.500.14720/28396
dc.identifier.volume 32 en_US
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Yuzuncu Yil Universitesi Tip Fakultesi en_US
dc.relation.ispartof Van Medical Journal en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Blood Coagulation Factors en_US
dc.subject Dopamine en_US
dc.subject Epinephrine en_US
dc.subject Hematocrit en_US
dc.subject Norepinephrine en_US
dc.subject Platelet Count en_US
dc.title The Effects of Epinephrine, Norepinephrine and Dopamine on Hemogram and Coagulation Parameters en_US
dc.type Article en_US
dspace.entity.type Publication

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