Safe Inhalational Anesthetics in Patients With Coronary Artery Disease: Effects of Sevoflurane and Desflurane on Ischemia-Modified Albumin Levels

Abstract

Introduction: Sevoflurane and desflurane are commonly used anesthetic agents with known cardiac side effects. Ischemia-modified albumin (IMA) is a useful biomarker that increases in cardiac conditions. This study investiga tes the effects of desflurane and sevoflurane on cardiac parameters and IMA levels in patients with coronary artery disease (CAD). Materials and Methods: Sixty CAD patients aged over 18 years scheduled for elective surgery were enrolled. Patients were rand omly divided into two groups: group I, desflurane (D) (n=30) and group II, sevoflurane (S) (n=30). Pre-and post-operative cardiac parameters were recorded for each patient. IMA measurement in serum was determined spectrophotometrically. Results: Postoperative IMA levels were significantly higher than preoperative IMA levels in both groups. The rate of change between post-and pre-operative IMA levels was significantly lower in group S than in group D. Postoperative heart rate (HR) and mean arterial pressure (MAP) levels were significantly lower than preoperative HR and MAP levels in both groups, whereas no significant differenc es were found between the two groups with regard to pre-and post-operative HR and MAP levels. Conclusions: Sevoflurane is safer and has fewer cardiac side effects in CAD patients than desflurane. However, there is a need for comprehensive new studies evaluating large patient groups investigating this situation. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.