Evaluation of Left Ventricular, Left Atrial, and Right Ventricular Function in Patients With Behçet's Disease by Strain Echocardiography

Abstract

Purpose: Behçet's disease (BD) can lead to a wide spectrum of cardiovascular manifestations. Strain echocardiography has emerged as a prominent modality in clinical practice owing to its significant prognostic value and ability to detect subclinical cardiac involvement in various cardiovascular diseases. This study was designed to evaluate left ventricular (LV), left atrium (LA), and right ventricular (RV) function in BD patients using strain echocardiography. Methods: A total of 61 participants were included in the study, comprising 27 patients with BD and 34 healthy controls. After medical histories and cardiac symptoms were obtained from all participants, basic echocardiographic parameters were recorded, and LV, LA, and RV functions were assessed using strain echocardiography. Results: No significant differences were observed between the two groups in terms of cardiac chamber dimensions and diastolic parameters. No significant difference was observed in global longitudinal strain values between the BD and control groups (p = 0.078). Similarly, no significant differences were found in right ventricular strain values. Regarding LA strain (LAS) parameters, LASr was found to be significantly lower in the BD group compared with the control group (p = 0.035). In the subgroup analysis comparing BD patients with and without uveitis, there were no statistically significant differences in LASr (p = 0.813), LAScd (p = 0.963), or LASct (p = 0.911). Conclusion: In conclusion, our study did not show any deterioration in LV or RV function in BD, but it did show deterioration in LA mechanical function. © 2026 Wiley Periodicals LLC.