Role of Trametes Multicolor in Green Nanotechnology Based Antioxidant, Antimicrobial, Lipid Peroxidation Inhibition From Fungi To Nanoparticles

Abstract

Fungi as source for new-bio based materials has a wide range of potential uses in the pharmaceutical, cosmetic, and medical sectors. They contain abundant natural bioactive chemical resources. This study reports the use of Trametes multicolour (Tm) mushroom extract for the ecofriendly production of silver nanoparticles (AgNPs). The color of the mushroom extract turns dark brown after a certain period of time when combined with metal. (AgNPs/Tm) and then showed maximum absorption at 318 nm, the wavelength of the surface plasmon resonance of AgNPs. The morphology of AgNPs/Tm was spherical and an EDX peak in the 3 keV region indicated the presence of Ag atoms. The binding properties of the biocomponents involved in NPs handling and stabilising the NPs were identified using Fourier transform infrared spectroscopy (FTIR) data. The synthesized NPs exhibited much higher stability (- 37.63 mV), antioxidant activity (IC50 18.92 mg/ml) and inhibition against lipid peroxidation (IC50 7.46 mg/ml) compared to the mushroom extract. Although there was a significant decrease in the hydrodynamic diameter of the NPs, there was an increase in their thermal stability and antimicrobial activity. As a result, the existence and current potential of a new biomaterial suitable for cost-effective and large-scale production in the synthesis of AgNPs has been demonstrated for the first time.