Effects of Subchronic Exposure To Thiocarbamide on Haematological and Biochemical Constituents of Rats

Abstract

The effects of sublethal concentration of thiocarbamide on various haematological and biochemical constituents of rat were investigated under laboratory conditions. 250 ppm of thiocarbamide was orally administered to eight ad libitum-fed rats during the test period of 25 days. Various haematological and biochemical constituents of the rat were determined after treatment with thiocarbamide, which caused significant increases in lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), while the level of alanine aminotransferase (ALT) was decreased. Aspartate aminotransferase (AST) and amylase level did not change. On the other hand, the treatment of rats with thiocarbamide also resulted in a different effect on the level of blood constituents compared to that of control rats. While the levels of white blood corpuscles (WBC) and thrombocytes (PLT) were increased significantly by thiocarbamide, the other parameters did not change. With regard to the biochemical characteristics, the levels of total cholesterol (TC) and high density lipoprotein cholesterol (HDLC) were increased significantly by thiocarbamide, but the other consituents did not change. It is concluded from the experiments of this study that thiocarbamide may cause toxicity in different tissues/organs of the laboratory in rats.