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A Novel Screening Test for Esophageal Squamous Cell Carcinoma: Sirtuin-3

dc.authorid Dulger, Cumhur/0000-0002-1844-7199
dc.authorid Kemik, Ozgur/0000-0002-4612-1428
dc.authorscopusid 6701581425
dc.authorscopusid 35483718900
dc.authorscopusid 6504566099
dc.authorscopusid 36774252500
dc.authorscopusid 6505748936
dc.authorwosid Kemik, Ozgur/Mgb-2153-2025
dc.contributor.author Cobanoglu, U.
dc.contributor.author Dulger, C.
dc.contributor.author Kemik, O.
dc.contributor.author Celik, S.
dc.contributor.author Sayir, F.
dc.date.accessioned 2025-05-10T17:50:39Z
dc.date.available 2025-05-10T17:50:39Z
dc.date.issued 2017
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Cobanoglu, U.; Sayir, F.] Yuzuncu Yil Univ, Dept Thorac Surg, Van, Turkey; [Dulger, C.] Yuzuncu Yil Univ, Dept Gastroenterol, Van, Turkey; [Kemik, O.] Yuzuncu Yil Univ, Dept Surg Oncol, Van, Turkey; [Celik, S.] Yuzuncu Yil Univ, Dept Gen Surg, Van, Turkey en_US
dc.description Dulger, Cumhur/0000-0002-1844-7199; Kemik, Ozgur/0000-0002-4612-1428 en_US
dc.description.abstract OBJECTIVE: Human sirtuin-3, a protein involved in the mediation of tumors, has been shown to be present in malignancies. The goal of this study was to measure serum sirtuin-3 levels in esophageal squamous cancer cells and to determine whether sirtuin-3 may possess predictive value in advanced cases of esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: A total of 130 ESCC patients and 50 healthy control subjects participated to the study. Serum sirtuin-3 levels for all 180 subjects were measured using enzyme-linked immunosorbent assay (ELISA). RESULTS: Median sirtuin-3 levels were significantly higher in patients with ESCC than in the control subjects. CONCLUSIONS: The presence of considerably elevated levels of sirtuin-3, could be a powerful mediator of advanced ESCC in ESCC patients, suggests that sirtuin-3 may be a useful indicator of the disease. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.endpage 5401 en_US
dc.identifier.issn 1128-3602
dc.identifier.issue 23 en_US
dc.identifier.pmid 29243781
dc.identifier.scopus 2-s2.0-85042148641
dc.identifier.scopusquality Q2
dc.identifier.startpage 5399 en_US
dc.identifier.uri https://hdl.handle.net/20.500.14720/17796
dc.identifier.volume 21 en_US
dc.identifier.wos WOS:000419143200015
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher verduci Publisher en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Sirtuin-3 en_US
dc.subject Screening en_US
dc.subject Esophageal Cancer Escc en_US
dc.title A Novel Screening Test for Esophageal Squamous Cell Carcinoma: Sirtuin-3 en_US
dc.type Article en_US

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