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Assessment of Serum Catalase, Reduced Glutathione, and Superoxide Dismutase Activities and Malondialdehyde Levels in Keratoconus Patients

dc.authorid Seven, Erbil/0000-0001-5629-291X
dc.authorscopusid 57195679419
dc.authorscopusid 57188826172
dc.authorwosid Seven, Erbil/Aaj-4613-2020
dc.contributor.author Tekin, Serek
dc.contributor.author Seven, Erbil
dc.date.accessioned 2025-05-10T17:12:51Z
dc.date.available 2025-05-10T17:12:51Z
dc.date.issued 2022
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Tekin, Serek; Seven, Erbil] Van Yuzuncu Yil Univ, Fac Med, Dept Ophthalmol, Van, Turkey en_US
dc.description Seven, Erbil/0000-0001-5629-291X en_US
dc.description.abstract Background: The aim of this study was to investigate the relationship between keratoconus disease and the antioxidant activities of catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD) and the level of the oxidative stress marker malondialdehyde (MDA) in serum. Methods: The study included 50 patients diagnosed with keratoconus and 53 healthy age- and sex-matched control subjects. The keratoconus patients were grouped according to the four keratoconus stages based on the modified Krumeich keratoconus classification system. The CAT, GSH and SOD activities and MDA levels in the serum samples collected from the patient and control groups were compared. Results: The mean serum CAT, GSH, SOD and MDA levels in the keratoconus group were determined to be 0.075 (0.074-0.078)U/L, 0.002 (0.001-0.006) mmol/ml, 1.56 (1.51-1.62)U/L and 1.69 (1.65-1.99) mmol/L, respectively, and those in the control group were determined to be 0.024 (0.013-0.037)U/L, 0.029 (0.018-0.049) mmol/ml, 4.13 (4.01-4.17) U/L and 0.74 (0.65-0.82) mmol/L. The serum GSH levels and SOD activity were significantly lower in the keratoconus group (p < 0.001 for both) than in the control group while the CAT activity and MDA levels were significantly higher (p < 0.001 for both). Conclusion: The low serum GSH levels and SOD activity and the high CAT activity and MDA levels observed in this study suggest the presence of oxidative stress and inadequate antioxidant defence mechanisms in keratoconus patients. The studied parameters may offer auxiliary markers for use in the diagnosis and treatment of the keratoconus disease and in its potential therapeutic targets in the future. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1038/s41433-021-01753-1
dc.identifier.endpage 2066 en_US
dc.identifier.issn 0950-222X
dc.identifier.issn 1476-5454
dc.identifier.issue 10 en_US
dc.identifier.pmid 34462580
dc.identifier.scopus 2-s2.0-85114000231
dc.identifier.scopusquality Q1
dc.identifier.startpage 2062 en_US
dc.identifier.uri https://doi.org/10.1038/s41433-021-01753-1
dc.identifier.uri https://hdl.handle.net/20.500.14720/8011
dc.identifier.volume 36 en_US
dc.identifier.wos WOS:000691179700006
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Springernature en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.title Assessment of Serum Catalase, Reduced Glutathione, and Superoxide Dismutase Activities and Malondialdehyde Levels in Keratoconus Patients en_US
dc.type Article en_US

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