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Peripheral Lymphocyte Dna Damage and Oxidative Status After Eradication Therapy in Patients Infected With Helicobacter Pylori

dc.authorid Bolukbas, Cengiz/0000-0002-8292-9256
dc.authorscopusid 36476941100
dc.authorscopusid 7006409671
dc.authorscopusid 6603332467
dc.authorscopusid 55924682900
dc.authorscopusid 55902404500
dc.authorscopusid 35554283900
dc.authorscopusid 9273761900
dc.authorwosid Kocyigit, Abdurrahim/P-8685-2019
dc.authorwosid Celik, Hakim/A-1789-2016
dc.authorwosid Horoz, Mehmet/Aah-8361-2019
dc.contributor.author Dulger, Ahmet C.
dc.contributor.author Aslan, Mehmet
dc.contributor.author Nazligul, Yasar
dc.contributor.author Horoz, Mehmet
dc.contributor.author Bolukbas, Cengiz
dc.contributor.author Bolukbas, Fusun F.
dc.contributor.author Kocyigit, Abdurrahim
dc.date.accessioned 2025-05-10T16:49:07Z
dc.date.available 2025-05-10T16:49:07Z
dc.date.issued 2011
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Aslan, Mehmet] Yuzuncu Yil Univ, Fac Med, Dept Internal Med, TR-65000 Van, Turkey; [Dulger, Ahmet C.] Yuzuncu Yil Univ, Fac Med, Dept Gastroenterol, TR-65000 Van, Turkey; [Nazligul, Yasar] Kecioren Res Hosp, Dept Gastroenterol, Ankara, Turkey; [Horoz, Mehmet] Harran Univ, Fac Med, Dept Internal Med, Sanliurfa, Turkey; [Bolukbas, Cengiz; Bolukbas, Fusun F.] Harran Univ, Fac Med, Dept Gastroenterol, Sanliurfa, Turkey; [Celik, Hakim; Kocyigit, Abdurrahim] Harran Univ, Fac Med, Dept Clin Biochem, Sanliurfa, Turkey en_US
dc.description Bolukbas, Cengiz/0000-0002-8292-9256 en_US
dc.description.abstract Introduction Helicobacter pylori infection has been shown to cause inflammation, increased production of reactive oxygen species, and oxidative DNA damage in the gastric mucosa. However, the effect of eradication treatment on DNA damage in patients infected with H. pylori is unclear. Objectives The objective of this study was to investigate the effect of eradication treatment on peripheral DNA damage and oxidative status in patients wth H. pylori infection. Patients and methods The study involved 42 patients positive for H. pylori (Hp+) and 25 patients negative for H. pylori (Hp-). Peripheral lymphocyte DNA damage was assessed using the alkaline comet assay and plasma oxidative status was determined. Measurements were conducted at baseline and 2 weeks after eradication treatment. Results The total antioxidant status (TAS) was lower in Hp+ patients than in Hp-patients (P <0.05), while the total oxidant status (TOS), oxidative stress index (OSI), and peripheral lymphocyte DNA damage were higher (P <0.001 for all parameters). TOS, OSI, and peripheral lymphocyte DNA damage were significantly lower after eradication treatment (P <0.001 for all parameters), while TAS was significantly higher (P <0.05). There was no correlation between TOS, OSI, peripheral lymphocyte DNA damage, and TAS and the histopathological degree of antral gastric inflammation in the Hp+ group (P >0.05). Conclusions Our results suggest that H. pylori eradication significantly decreases peripheral lymphocyte DNA damage and oxidative stress. Eradication treatment might help prevent the development of gastric cancer in patients with H. pylori infection. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.20452/pamw.1107
dc.identifier.endpage 432 en_US
dc.identifier.issn 0032-3772
dc.identifier.issue 12 en_US
dc.identifier.pmid 22012003
dc.identifier.scopus 2-s2.0-84855288859
dc.identifier.scopusquality Q2
dc.identifier.startpage 428 en_US
dc.identifier.uri https://doi.org/10.20452/pamw.1107
dc.identifier.uri https://hdl.handle.net/20.500.14720/1740
dc.identifier.volume 121 en_US
dc.identifier.wos WOS:000298667500002
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Medycyna Praktyczna en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Helicobacter Pylori en_US
dc.subject Oxidative Stress Index en_US
dc.subject Peripheral Lymphocyte Dna Damage en_US
dc.subject Total Antioxidant Status en_US
dc.subject Total Oxidant Status en_US
dc.title Peripheral Lymphocyte Dna Damage and Oxidative Status After Eradication Therapy in Patients Infected With Helicobacter Pylori en_US
dc.type Article en_US

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