YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.
 

Hepatoprotective and Tnf-Α Inhibitory Activity of Zosima Absinthifolia Extracts and Coumarins

Simple item page
dc.authorid Smejkal, Karel/0000-0002-4336-7924
dc.authorid Saltan, Hayriye Gulcin/0000-0001-6633-0713
dc.authorid Hosek, Jan/0000-0003-0975-1671
dc.authorscopusid 15020374700
dc.authorscopusid 6505981605
dc.authorscopusid 7005912992
dc.authorscopusid 57202642839
dc.authorscopusid 24484447300
dc.authorscopusid 36904440400
dc.authorwosid Dall'Acqua, Stefano/C-1353-2013
dc.authorwosid Ozbek, Hanefi/O-3472-2019
dc.authorwosid Iscan, Gülçin/Aag-8646-2020
dc.authorwosid Šmejkal, Karel/Abf-5925-2020
dc.authorwosid Hosek, Jan/B-6274-2009
dc.contributor.author Bahadir, Ozlem
dc.contributor.author Citoglu, Gulcin Saltan
dc.contributor.author Ozbek, Hanefi
dc.contributor.author Dall'Acqua, Stefano
dc.contributor.author Hosek, Jan
dc.contributor.author Smejkal, Karel
dc.date.accessioned 2025-05-10T16:49:45Z
dc.date.available 2025-05-10T16:49:45Z
dc.date.issued 2011
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Hosek, Jan; Smejkal, Karel] Univ Vet, Fac Pharm, Dept Nat Drugs, Brno 61242, Czech Republic; [Bahadir, Ozlem; Citoglu, Gulcin Saltan] Ankara Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey; [Ozbek, Hanefi] Yuzuncu Yil Univ, Fac Med, Dept Pharmacol, TR-65300 Van, Turkey; [Dall'Acqua, Stefano] Univ Padua, Dipartimento Sci Farmaceut, Nat Prod Lab NPL, I-35100 Padua, Italy en_US
dc.description Smejkal, Karel/0000-0002-4336-7924; Saltan, Hayriye Gulcin/0000-0001-6633-0713; Hosek, Jan/0000-0003-0975-1671 en_US
dc.description.abstract Zosima absinthifolia (ZA) extracts and the coumarins (+)-columbianadin and (-)-deltoin were evaluated for their potential hepatoprotective and antiinflamatory effects in a CCl4-induced hepatotoxicity assay in rats and by the inhibition of TNF-alpha production on LPS-stimulated THP-1 macrophages, respectively. Both the ZA extracts and the coumarins showed hepatoprotective activity confirmed by monitoring the ALT/AST levels and by histopathological examination. The antiinflamatory activity, proved by the inhibition of TNF-alpha production, was found to be higher for the n-hexane root extract than for coumarins, suggesting synergic potential of the extract. The concentration of (-)-deltoin and (+)-columbianadin in extracts was determined by HPLC analysis. (c) 2011 Elsevier B.V. All rights reserved. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1016/j.fitote.2010.12.007
dc.identifier.endpage 459 en_US
dc.identifier.issn 0367-326X
dc.identifier.issn 1873-6971
dc.identifier.issue 3 en_US
dc.identifier.pmid 21185922
dc.identifier.scopus 2-s2.0-79951680772
dc.identifier.scopusquality Q2
dc.identifier.startpage 454 en_US
dc.identifier.uri https://doi.org/10.1016/j.fitote.2010.12.007
dc.identifier.uri https://hdl.handle.net/20.500.14720/1915
dc.identifier.volume 82 en_US
dc.identifier.wos WOS:000288354700025
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject (+)-Columbianadin en_US
dc.subject (-)-Deltoin en_US
dc.subject Furanocoumarin en_US
dc.subject Hepatoprotective Activity en_US
dc.subject Tnf-Alpha en_US
dc.subject Zosima en_US
dc.title Hepatoprotective and Tnf-Α Inhibitory Activity of Zosima Absinthifolia Extracts and Coumarins en_US
dc.type Article en_US

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu