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Neuroprotective Effects of Dietary Borax in the Brain Tissue of Rainbow Trout (Oncorhynchus Mykiss) Exposed To Copper-Induced Toxicity

dc.authorid Comakli, Selim/0000-0002-8744-7686
dc.authorid Cilingir Yeltekin, Asli/0000-0003-0071-7434
dc.authorid Bolat, Ismail/0000-0003-1398-7046
dc.authorid Alak, Gonca/0000-0002-7539-1152
dc.authorid Parlak, Veysel/0000-0002-3459-7963
dc.authorid Ucar, Arzu/0000-0001-5675-9401
dc.authorscopusid 23395887300
dc.authorscopusid 36524329100
dc.authorscopusid 56189749500
dc.authorscopusid 56524543700
dc.authorscopusid 55636597200
dc.authorscopusid 57190807918
dc.authorscopusid 6603374161
dc.authorwosid Bolat, Ismail/Aau-9698-2021
dc.authorwosid Atamanalp, Muhammed/Aag-2950-2020
dc.authorwosid Parlak, Veysel/L-3436-2018
dc.authorwosid Ozkaraca, Mustafa/Lmq-0756-2024
dc.authorwosid Alak, Gonca/Hzk-0144-2023
dc.authorwosid Uçar, Arzu/Aaa-2325-2022
dc.authorwosid Aslı/Afm-3417-2022
dc.contributor.author Alak, Gonca
dc.contributor.author Ucar, Arzu
dc.contributor.author Yeltekin, Asli Cilingir
dc.contributor.author Comakli, Selim
dc.contributor.author Parlak, Veysel
dc.contributor.author Tas, Ismail Hakki
dc.contributor.author Turkez, Hasan
dc.date.accessioned 2025-05-10T17:43:41Z
dc.date.available 2025-05-10T17:43:41Z
dc.date.issued 2018
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Alak, Gonca; Ucar, Arzu; Parlak, Veysel; Atamanalp, Muhammed] Ataturk Univ, Dept Aquaculture, Fac Fisheries, TR-25240 Erzurum, Turkey; [Yeltekin, Asli Cilingir] Yuzuncu Yil Univ, Fac Sci, Dept Chem, TR-65080 Van, Turkey; [Comakli, Selim; Ozkaraca, Mustafa; Kirman, Esra Manavoglu; Bolat, Ismail] Ataturk Univ, Fac Vet, Dept Pathol, TR-25240 Erzurum, Turkey; [Tas, Ismail Hakki] Qiagen, TR-25240 Erzurum, Turkey; [Topal, Ahmet] Ataturk Univ, Fac Fisheries, Dept Basic Sci, TR-25240 Erzurum, Turkey; [Turkez, Hasan] Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, TR-25050 Erzurum, Turkey en_US
dc.description Comakli, Selim/0000-0002-8744-7686; Cilingir Yeltekin, Asli/0000-0003-0071-7434; Bolat, Ismail/0000-0003-1398-7046; Alak, Gonca/0000-0002-7539-1152; Parlak, Veysel/0000-0002-3459-7963; Ucar, Arzu/0000-0001-5675-9401 en_US
dc.description.abstract We aimed to investigate the modulating effects of dietary borax on the pathways in rainbow trout brain exposed to copper. For this aim, a comprehensive assessment was performed including biochemical (acetylcholinesterase (AChE), malondialdehyde (MDA), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG), and caspase-3 levels) and transcriptional parameters (heat shock protein 70 (HSP70) and cytochromes P450 (CYP1A), glutathione peroxidase (gpx), superoxide dismutase (sod), and catalase (cat)) parameters and immunohistochemically staining of 8-OHdG. Special fish feed diets were prepared for the trial. These diets contained different concentrations of borax (1.25, 2.5, and 5mg/kg) and/or copper (500 and 1000mg/kg) at the period of pre- and co-treatment strategies for 21days. At the end of the treatment periods, brain tissue was sampled for each experimental group. As a result, the biochemical parameters were increased and AChE activity decreased in the copper and copper-combined groups in comparison with the control group and also with only borax applications (p<0.05). We observed an increase or decrease in particular biochemical parameters for the borax group in every application and we established that borax had protective effect against copper toxicity by decreasing and/or increasing the relevant biochemical parameters in brain tissue of fish. The biochemical results of borax and its combinations corresponded to the observations of gene expression data, which similarly concluded that HSP70 and CYP1A genes were strongly induced by copper (p<0.05). In addition, the expression levels of the sod, cat, and gpx genes in the fish brains exposed to borax and the borax combination groups were significantly higher than the only copper-treated groups. In conclusion, borax supplementation provided significant protection against copper-induced neurotoxicity in trout. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1007/s10695-018-0530-0
dc.identifier.endpage 1420 en_US
dc.identifier.issn 0920-1742
dc.identifier.issn 1573-5168
dc.identifier.issue 5 en_US
dc.identifier.pmid 29959587
dc.identifier.scopus 2-s2.0-85049132089
dc.identifier.scopusquality Q3
dc.identifier.startpage 1409 en_US
dc.identifier.uri https://doi.org/10.1007/s10695-018-0530-0
dc.identifier.uri https://hdl.handle.net/20.500.14720/15938
dc.identifier.volume 44 en_US
dc.identifier.wos WOS:000444021700012
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Springer en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Brain en_US
dc.subject Borax en_US
dc.subject Fish en_US
dc.subject Toxicity Mechanism en_US
dc.subject Copper Toxicity en_US
dc.subject Molecular Genetic Response en_US
dc.subject Neurotoxicity en_US
dc.title Neuroprotective Effects of Dietary Borax in the Brain Tissue of Rainbow Trout (Oncorhynchus Mykiss) Exposed To Copper-Induced Toxicity en_US
dc.type Article en_US

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