YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.
 

Phytochemical Analysis of Podospermum and Scorzonera N-Hexane Extracts and the Hplc Quantitation of Triterpenes

dc.authorid Smejkal, Karel/0000-0002-4336-7924
dc.authorid Ozgokce, Fevzi/0000-0002-3119-8561
dc.authorid Saltan, Hayriye Gulcin/0000-0001-6633-0713
dc.authorid Ozbilgin, Serkan/0000-0002-3945-6756
dc.authorid Bahadir Acikara, Ozlem/0000-0003-0809-784X
dc.authorscopusid 15020374700
dc.authorscopusid 55935398700
dc.authorscopusid 57215911650
dc.authorscopusid 57202642839
dc.authorscopusid 57192091381
dc.authorscopusid 55989906300
dc.authorscopusid 7003502257
dc.authorwosid Acıkara, Özlem/Aah-4682-2020
dc.authorwosid Dall'Acqua, Stefano/C-1353-2013
dc.authorwosid Iscan, Gülçin/Aag-8646-2020
dc.authorwosid Rjaskova, Veronika/Aad-3051-2020
dc.authorwosid Šmejkal, Karel/Abf-5925-2020
dc.authorwosid Ozgokce, Fevzi/V-2091-2019
dc.contributor.author Bahadir-Acikara, Ozlem
dc.contributor.author Ozbilgin, Serkan
dc.contributor.author Saltan-Iscan, Gulcin
dc.contributor.author Dall'Acqua, Stefano
dc.contributor.author Rjaskova, Veronika
dc.contributor.author Ozgokce, Fevzi
dc.contributor.author Smejkal, Karel
dc.date.accessioned 2025-05-10T17:05:06Z
dc.date.available 2025-05-10T17:05:06Z
dc.date.issued 2018
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Bahadir-Acikara, Ozlem; Ozbilgin, Serkan; Saltan-Iscan, Gulcin] Ankara Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey; [Dall'Acqua, Stefano] Univ Padua, Dept Pharmaceut Sci, Via Marzolo 5, I-35100 Padua, Italy; [Rjaskova, Veronika; Suchy, Vaclav; Smejkal, Karel] Univ Vet & Pharmaceut Sci Brno, Fac Pharm, Dept Nat Drugs, Palackeho Trida 1946-1, CZ-61242 Brno, Czech Republic; [Ozgokce, Fevzi] Yuzuncu Yil Univ, Fac Art & Sci, Dept Biol, TR-65080 Van, Turkey en_US
dc.description Smejkal, Karel/0000-0002-4336-7924; Ozgokce, Fevzi/0000-0002-3119-8561; Saltan, Hayriye Gulcin/0000-0001-6633-0713; Ozbilgin, Serkan/0000-0002-3945-6756; Bahadir Acikara, Ozlem/0000-0003-0809-784X en_US
dc.description.abstract Previously tested n-hexane extracts of the Scorzonera latifolia showed promising bioactivity in vivo. Because triterpenes could account for this activity, n-hexane extracts were analyzed by HPLC to identify and quantify the triterpenes as the most abundant constituents. Other Scorzonera and Podospermum species, potentially containing triterpenic aglycones, were included in the study. An HPLC method for simultaneous determination of triterpene aglycones was therefore developed for analysis of Podospermum and Scorzonera species. n-Hexane extracts of root and aerial parts of S. latifolia, ten other Scorzonera species and two Podospermum species were studied to compare the content of triterpenes. HPLC was used for the qualitative and quantitative analysis of -amyrin, lupeol, lupeol acetate, taraxasteryl acetate, 3--hydroxy-fern-7-en-6-one acetate, urs-12-en-11-one-3-acetyl, 3--hydroxy-fern-8-en-7-one acetate, and olean-12-en-11-one-3-acetyl. Limits of detection and quantification were determined for each compound. HPLC fingerprinting of n-hexane extracts of Podospermum and Scorzonera species revealed relatively large amounts of triterpenes in a majority of investigated taxa. Lupeol, lupeol acetate, and taraxasteryl acetate were found in a majority of the species, except S. acuminata. The presence of -amyrin, 3-hydroxy-fern-7-en-6-one-acetate, urs-12-en-11-one-3-acetyl, 3-hydroxy-fern-8-en-7-one-acetate, and olean-12-en-11-one-3-acetyl was detected in varying amounts. The triterpene content could correlate with the analgesic and anti-inflammatory activity of Scorzonera, which was previously observed and Scorzonera species that have been determined to contain triterpenes in large amounts and have not yet been tested for their analgesic activity should be tested for their potential analgesic and anti-inflammatory potential. The presented HPLC method can be used for analysis of triterpene aglycones, for example dedicated to chemosystematic studies of the Scorzonerinae. en_US
dc.description.sponsorship IGA UVPS Brno [320/2016/FaF] en_US
dc.description.sponsorship Authors are thankful for the support of IGA UVPS Brno 320/2016/FaF. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.3390/molecules23071813
dc.identifier.issn 1420-3049
dc.identifier.issue 7 en_US
dc.identifier.pmid 30037105
dc.identifier.scopus 2-s2.0-85056250790
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.3390/molecules23071813
dc.identifier.uri https://hdl.handle.net/20.500.14720/6214
dc.identifier.volume 23 en_US
dc.identifier.wos WOS:000445301800316
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Mdpi en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Hplc en_US
dc.subject Podospermum en_US
dc.subject Scorzonera en_US
dc.subject Triterpenes en_US
dc.title Phytochemical Analysis of Podospermum and Scorzonera N-Hexane Extracts and the Hplc Quantitation of Triterpenes en_US
dc.type Article en_US

Files