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Oxidative Dna Damage and Nox4 Levels in Children With Undescended Testes

dc.authorid Alp, Hamit Hakan/0000-0002-9202-4944
dc.authorid Ayengin, Kemal/0000-0002-1633-3200
dc.authorscopusid 41560903900
dc.authorscopusid 41561025600
dc.authorscopusid 24328770500
dc.authorwosid Hakan, Hamit/U-2671-2018
dc.authorwosid Ayengin, Kemal/Abi-4555-2020
dc.contributor.author Avci, Veli
dc.contributor.author Ayengin, Kemal
dc.contributor.author Alp, Hamit Hakan
dc.date.accessioned 2025-05-10T17:34:54Z
dc.date.available 2025-05-10T17:34:54Z
dc.date.issued 2019
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Avci, Veli; Ayengin, Kemal] Van Yuzuncu Yil Univ, Dept Pediat Surg, Van, Turkey; [Alp, Hamit Hakan] Van Yuzuncu Yil Univ, Dept Biochem, Van, Turkey en_US
dc.description Alp, Hamit Hakan/0000-0002-9202-4944; Ayengin, Kemal/0000-0002-1633-3200 en_US
dc.description.abstract Background Undescended testis (UDT) is a common urological disorder. Patients with UDT have a risk of malignancy and infertility. The development of these conditions may be due to oxidative stress mediated by reactive oxygen species. The aim of this study was to investigate the relationship between these parameters by detecting oxidative DNA damage (8-hydroxy 2 deoxyguanosine/10 (6) deoxyguanosine), ischemia-modified albumin (IMA), malondialdehyde (MDA), and nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) levels in children with UDT and healthy control group. Materials and Methods The blood samples were obtained from 30 patients with UDT and 40 healthy male subjects. The levels of oxidative DNA damage were detected by high-pressure liquid chromatography method. We used commercially available kits that use enzyme-linked immunosorbent assay method to measure IMA, MDA, and NOX4 levels. Results The levels of MDA, IMA, NOX4, and oxidative DNA damage in children with UDT were statistically significantly higher than control group. In addition, we found that the levels of NOX4, IMA, and oxidative DNA damage after 12 months of age was significantly higher than before 12 months of age. Conclusion We identified increased lipid peroxidation, oxidative DNA damage, IMA, and NOX4 levels in children with UDT. Delay in the treatment of UDT may cause oxidative damage. That is why, according to us the antioxidant treatment may be beneficial in children with UDT. en_US
dc.description.sponsorship Research Fund of the Yuzuncu Yil University [THD-2018-7437] en_US
dc.description.sponsorship This work was supported by the Research Fund of the Yuzuncu Yil University. Project number: THD-2018-7437. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1055/s-0039-1692167
dc.identifier.endpage 550 en_US
dc.identifier.issn 0939-7248
dc.identifier.issn 1439-359X
dc.identifier.issue 6 en_US
dc.identifier.pmid 31167233
dc.identifier.scopus 2-s2.0-85075799736
dc.identifier.scopusquality Q2
dc.identifier.startpage 545 en_US
dc.identifier.uri https://doi.org/10.1055/s-0039-1692167
dc.identifier.uri https://hdl.handle.net/20.500.14720/13954
dc.identifier.volume 29 en_US
dc.identifier.wos WOS:000502379500010
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Georg Thieme verlag Kg en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Undescended Testis en_US
dc.subject Ischemia-Modified Albumin en_US
dc.subject Malondialdehyde en_US
dc.subject Nox4 en_US
dc.subject Oxidative Dna Damage en_US
dc.title Oxidative Dna Damage and Nox4 Levels in Children With Undescended Testes en_US
dc.type Article en_US

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