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Borax Relieved the Acrylamide-Induced Hematotoxic, Hepatotoxic, Immunotoxic and Genotoxic Damages in Rainbow Trout by Regulating Apoptosis and Nrf2 Signaling Pathway

dc.authorid Cilingir Yeltekin, Asli/0000-0003-0071-7434
dc.authorscopusid 6603374161
dc.authorscopusid 9134233800
dc.authorscopusid 56189749500
dc.authorscopusid 54385688800
dc.authorscopusid 36524329100
dc.authorscopusid 57520408900
dc.authorscopusid 57226850440
dc.authorwosid Parlak, Veysel/L-3436-2018
dc.authorwosid Çağlar Yıldırım, Özge/Aay-9490-2021
dc.authorwosid , Aslı/Afm-3417-2022
dc.authorwosid Türkez, Hasan/Aaq-4905-2020
dc.authorwosid Atamanalp, Muhammed/Aag-2950-2020
dc.authorwosid Uçar, Arzu/Aaa-2325-2022
dc.authorwosid Alak, Gonca/Hzk-0144-2023
dc.contributor.author Atamanalp, Muhammed
dc.contributor.author Turkez, Hasan
dc.contributor.author Yeltekin, Asli cilingir
dc.contributor.author Ozgeris, Fatma Betuel
dc.contributor.author Ucar, Arzu
dc.contributor.author caglar, Ozge
dc.contributor.author Alak, Gonca
dc.date.accessioned 2025-05-10T17:11:59Z
dc.date.available 2025-05-10T17:11:59Z
dc.date.issued 2022
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Atamanalp, Muhammed; Ucar, Arzu] Ataturk Univ, Fac Fisheries, Dept Aquaculture, Erzurum, Turkey; [Turkez, Hasan] Ataturk Univ, Fac Med, Dept Basic Med Sci, Erzurum, Turkey; [Yeltekin, Asli cilingir] Yuzuncu Yil Univ, Fac Sci, Dept Chem, Van, Turkey; [Ozgeris, Fatma Betuel] Ataturk Univ, Fac Hlth Sci, Dept Nutr & Dietet, Erzurum, Turkey; [caglar, Ozge; Oner, Sena] Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, Erzurum, Turkey; [Parlak, Veysel] Ataturk Univ, Fac Fisheries, Dept Basic Sci, Erzurum, Turkey; [Alak, Gonca] Ataturk Univ, Fac Fisheries, Dept Seafood Proc Technol, Erzurum, Turkey en_US
dc.description Cilingir Yeltekin, Asli/0000-0003-0071-7434 en_US
dc.description.abstract Acrylamide(AA) is a compound with wide usage areas including paper, dyes, and plastics industries. Due to its broad spectrum and water solubility suggest that this vinyl compound may cause serious environmental problems. AA was shown to exhibit neurotoxic, immunotoxic, reproductive toxicant as well as carcinogenic potency on animals. Especially in recent years, the therapeutic effects of boron and boron containing compounds like borax(BX), ulexite(ULX) and colemanite(COL) had been reported. However, the ameliorative potential by boron compounds against AA-induced toxicities had not been investigated yet. Therefore, in this investigation rainbow trout were exposed acutely to AA in the presence and absence of BX. The hematological indices and genotoxic end-points were examined in the fish blood tissue. In addition to oxidative stress response, the levels of DNA damage, CASP3, TNF-alpha, Nrf-2 as well as IL-6 amounts were determined in both blood and liver tissues of fish. The obtained results executed that AA induced toxic conditions in both tissues. In fact, an increase in the amount of oxidative stress and ROS, and a decrease in GSH levels were observed. AA exposure led to an increase in CASP3levels and 8-OHdG formation. It was also found that Nrf-2 pathway contributed to the initiation of oxidative stress that associated with AA-induced toxicity. On the contrary, our findings indicated that co-exposure of BX with AA elicited oxidative stress and cell death. In a conclusion BX was suggested as a useful and effective natural agent for the prevention and early treatment of AA toxicity in fish. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1016/j.cbpc.2022.109396
dc.identifier.issn 1532-0456
dc.identifier.issn 1878-1659
dc.identifier.pmid 35710039
dc.identifier.scopus 2-s2.0-85132532004
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.1016/j.cbpc.2022.109396
dc.identifier.uri https://hdl.handle.net/20.500.14720/7773
dc.identifier.volume 259 en_US
dc.identifier.wos WOS:000829570800005
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Elsevier Science inc en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Acrylamide en_US
dc.subject Borax en_US
dc.subject Genotoxicity en_US
dc.subject Immunotoxicity en_US
dc.subject Oxidative Dna Damage en_US
dc.subject Rainbow Trout en_US
dc.title Borax Relieved the Acrylamide-Induced Hematotoxic, Hepatotoxic, Immunotoxic and Genotoxic Damages in Rainbow Trout by Regulating Apoptosis and Nrf2 Signaling Pathway en_US
dc.type Article en_US

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