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Acute Amitriptyline Intoxication

dc.authorid Akbayram, Sinan/0009-0001-0816-4144
dc.authorid Akbayram, Sinan/0000-0001-7410-4310
dc.authorscopusid 7101974609
dc.authorscopusid 6602406361
dc.authorscopusid 7003543848
dc.authorscopusid 7005912992
dc.authorscopusid 56582813800
dc.authorscopusid 6507594315
dc.authorscopusid 56186063400
dc.authorwosid Akbayram, Sinan/Aag-5737-2020
dc.authorwosid Erol, Muhammet/T-3728-2019
dc.authorwosid Odabaş, Dursun/Mbh-2762-2025
dc.authorwosid Ozbek, Hanefi/O-3472-2019
dc.contributor.author Çaksen, H
dc.contributor.author Akbayram, S
dc.contributor.author Odabas, D
dc.contributor.author Özbek, H
dc.contributor.author Erol, M
dc.contributor.author Akgün, C
dc.contributor.author Yilmaz, C
dc.date.accessioned 2025-05-10T17:28:58Z
dc.date.available 2025-05-10T17:28:58Z
dc.date.issued 2006
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Yuzuncu Yil Univ, Fac Med, Dept Pediat, TR-65200 Van, Turkey; Yuzuncu Yil Univ, Fac Med, Dept Pharmacol, TR-65200 Van, Turkey en_US
dc.description Akbayram, Sinan/0009-0001-0816-4144; Akbayram, Sinan/0000-0001-7410-4310 en_US
dc.description.abstract The tricyclic antidepressant agents, particularly amitriptyline and dothiepin, are recognized for their potentially lethal cardiovascular and neurological effects in poisoned patients. In this article, the clinical and laboratory findings of 44 children with amitriptyline intoxication are reviewed. Our purpose was to investigate amitriptyline intoxication in childhood. Of 44 patients, 21 ( 47.7%) were boys, 23 ( 52.3%) were girls, and the ages ranged from 12 months to 14 years ( mean +/- SD; 4.09 +/- 2.9 years). All children except one who took an overdose of amitriptyline to decrease his pain accidentally ingested an overdose of amitriptyline. The amount of amitriptyline ingested was between 2 mg/kg and 97.5 mg/kg (mean +/- SD; 13.6 +/- 17.7 mg/kg per dose) (the drug dosage was not known in 13 children). The most commonly observed clinical and laboratory findings were lethargy, tachycardia, convulsion, hyperglycemia and leukocytosis. In all patients except for two children who died the abnormal clinical and laboratory findings returned to normal within a few days after admission and they were discharged from the hospital in good health within the fourth day of admission. One of the children ingested 97.5 mg/kg amitriptyline and probably died due to status epilepticus and another child who died ingested 36 mg/kg amitriptyline and died due to cardiopulmonary arrest. In conclusion, our findings showed that initial symptoms and signs of acute amitriptyline intoxication appeared severe, but they disappeared with only supportive care required in most children except for cases that ingested high doses of drug within a few days. In contrast to adults, we infrequently noted respiratory insufficiency, arrhythmia and hypotension in children with acute amitriptyline intoxication. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1191/0960327106ht511oa
dc.identifier.endpage 110 en_US
dc.identifier.issn 0960-3271
dc.identifier.issn 1477-0903
dc.identifier.issue 3 en_US
dc.identifier.pmid 16634328
dc.identifier.scopus 2-s2.0-33646010690
dc.identifier.scopusquality Q2
dc.identifier.startpage 107 en_US
dc.identifier.uri https://doi.org/10.1191/0960327106ht511oa
dc.identifier.uri https://hdl.handle.net/20.500.14720/12205
dc.identifier.volume 25 en_US
dc.identifier.wos WOS:000236012200001
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Sage Publications Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Amitriptyline en_US
dc.subject Child en_US
dc.subject Intoxication en_US
dc.title Acute Amitriptyline Intoxication en_US
dc.type Article en_US

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