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No Effect of Long-Term Valproate Therapy on Thyroid and Parathyroid Functions in Children

dc.authorscopusid 7101974609
dc.authorscopusid 56011002500
dc.authorscopusid 6603814316
dc.authorscopusid 7003543848
dc.authorscopusid 56186063400
dc.authorscopusid 6603968029
dc.authorwosid Odabaş, Dursun/Mbh-2762-2025
dc.authorwosid Dülger, Haluk/Isa-3510-2023
dc.contributor.author Çaksen, H
dc.contributor.author Dülger, H
dc.contributor.author Cesur, Y
dc.contributor.author Odabas, D
dc.contributor.author Tuncer, O
dc.contributor.author Atas, B
dc.date.accessioned 2025-05-10T17:15:11Z
dc.date.available 2025-05-10T17:15:11Z
dc.date.issued 2002
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Yuzuncu Yil Univ, Dept Pediat, Fac Med, Van, Turkey; Yuzuncu Yil Univ, Dept Biochem, Fac Med, Van, Turkey; Yuzuncu Yil Univ, Dept Pediat, Fac Med, Van, Turkey en_US
dc.description.abstract In this study, we studied serum calcium, phosphorus, alkaline phosphatase, thyroid hormones (total thyroxine, free thyroxine, thyroid-stimulating hormone), parathyroid hormone, and osteocalcine levels in children with epilepsy who had been receiving long-term valproate (VPA) therapy in order to determine whether there was any effect of VPA therapy on these hormones. The study included 31 patients with epilepsy receiving VPA and 22 healthy age-matched controls. The age ranged from 15 months to 16 years and 18 months to 17 years in the study and control group, respectively. The duration of VPA use was between 12 months and 5 years (1.93 +/- 1.90 years). When comparing the results, we did not find any significant difference in any of the parameters, including serum calcium, phosphorus, alkaline phosphatase, osteocalcine, and thyroid and parathyroid hormone levels, between the study and control group. We suggest that VPA can safely be used with regard to thyroid and parathyroid dysfunction in childhood epilepsy. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1080/00207450290158269
dc.identifier.endpage 1374 en_US
dc.identifier.issn 0020-7454
dc.identifier.issue 11 en_US
dc.identifier.pmid 12625196
dc.identifier.scopus 2-s2.0-18744409146
dc.identifier.scopusquality Q2
dc.identifier.startpage 1371 en_US
dc.identifier.uri https://doi.org/10.1080/00207450290158269
dc.identifier.uri https://hdl.handle.net/20.500.14720/8553
dc.identifier.volume 112 en_US
dc.identifier.wos WOS:000179616600007
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Taylor & Francis Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Parathyroid en_US
dc.subject Thyroid en_US
dc.subject Valproate en_US
dc.title No Effect of Long-Term Valproate Therapy on Thyroid and Parathyroid Functions in Children en_US
dc.type Article en_US

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