A Novel Class for Carbonic Anhydrases Inhibitors and Evaluation of Their Non-Zinc Binding
| dc.authorid | Gulcin, Ilhami/0000-0001-5993-1668 | |
| dc.authorid | Menges, Nurettin/0000-0002-5990-6275 | |
| dc.authorscopusid | 57170612000 | |
| dc.authorscopusid | 57221383476 | |
| dc.authorscopusid | 35509141500 | |
| dc.authorscopusid | 23973608700 | |
| dc.authorwosid | Tan Uygun, Meltem/Aad-1641-2021 | |
| dc.authorwosid | Kuzu, Burak/Aae-1597-2022 | |
| dc.authorwosid | Gulcin, Ilhami/F-1428-2014 | |
| dc.authorwosid | Menges, Nurettin/F-9678-2016 | |
| dc.contributor.author | Kuzu, Burak | |
| dc.contributor.author | Tan, Meltem | |
| dc.contributor.author | Gulcin, Ilhami | |
| dc.contributor.author | Menges, Nurettin | |
| dc.date.accessioned | 2025-05-10T17:20:49Z | |
| dc.date.available | 2025-05-10T17:20:49Z | |
| dc.date.issued | 2021 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Kuzu, Burak; Tan, Meltem; Menges, Nurettin] Yuzuncu Yil Univ, Pharmaceut Chem Sect, TR-65080 Tusba, Van, Turkey; [Gulcin, Ilhami] Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey | en_US |
| dc.description | Gulcin, Ilhami/0000-0001-5993-1668; Menges, Nurettin/0000-0002-5990-6275 | en_US |
| dc.description.abstract | In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89-115.5 nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure-activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non-zinc binding. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded - Index Chemicus | |
| dc.identifier.doi | 10.1002/ardp.202100188 | |
| dc.identifier.issn | 0365-6233 | |
| dc.identifier.issn | 1521-4184 | |
| dc.identifier.issue | 10 | en_US |
| dc.identifier.pmid | 34096646 | |
| dc.identifier.scopus | 2-s2.0-85107318417 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https://doi.org/10.1002/ardp.202100188 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/10213 | |
| dc.identifier.volume | 354 | en_US |
| dc.identifier.wos | WOS:000658294300001 | |
| dc.identifier.wosquality | Q1 | |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley-v C H verlag Gmbh | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Carbonic Anhydrase Inhibition | en_US |
| dc.subject | Docking | en_US |
| dc.subject | Imidazole Ring | en_US |
| dc.subject | Non-Zinc Binding | en_US |
| dc.subject | Sar Study | en_US |
| dc.title | A Novel Class for Carbonic Anhydrases Inhibitors and Evaluation of Their Non-Zinc Binding | en_US |
| dc.type | Article | en_US |