YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.
 

Hepatoprotective and Anti-Inflammatory Activities of Plantago Major L

dc.authorid Erten, Remzi/0000-0001-7775-5792
dc.authorid Oner, Ahmet Cihat/0000-0001-6614-4347
dc.authorscopusid 7003316142
dc.authorscopusid 7005912992
dc.authorscopusid 24461417500
dc.authorscopusid 24177780200
dc.authorscopusid 55391495500
dc.authorscopusid 7103213356
dc.authorwosid Ozbek, Hanefi/O-3472-2019
dc.authorwosid Cengiz, Nureddin/A-4949-2018
dc.authorwosid Erten, Remzi/V-5175-2019
dc.authorwosid Öner, Ahmet Cihat/Aae-2852-2021
dc.authorwosid Turel, Idris/Lwj-9996-2024
dc.contributor.author Turel, Idris
dc.contributor.author Ozbek, Hanefi
dc.contributor.author Erten, Remzi
dc.contributor.author Oner, Ahmet Cihat
dc.contributor.author Cengiz, Nureddin
dc.contributor.author Yilmaz, Orhan
dc.date.accessioned 2025-05-10T17:19:39Z
dc.date.available 2025-05-10T17:19:39Z
dc.date.issued 2009
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Turel, Idris; Oner, Ahmet Cihat; Yilmaz, Orhan] Yuzuncu Yil Univ, Dept Pharmacol & Toxicol, TR-65300 Van, Turkey; [Ozbek, Hanefi] Yuzuncu Yil Univ, Dept Pharmacol, TR-65300 Van, Turkey; [Erten, Remzi] Yuzuncu Yil Univ, Dept Pathol, TR-65300 Van, Turkey; [Cengiz, Nureddin] Yuzuncu Yil Univ, Dept Histol Embryol, TR-65300 Van, Turkey en_US
dc.description Erten, Remzi/0000-0001-7775-5792; Oner, Ahmet Cihat/0000-0001-6614-4347 en_US
dc.description.abstract Objective: The aim of this study was to investigate anti-inflammatory and hepatoprotective activities of Plantago major L. (PM). Materials and Methods: Anti-inflammatory activity: Control and reference groups were administered isotonic saline solution (ISS) and indomethacin, respectively. Plantago major groups were injected PM in doses of 5 mg/kg (PM-I), 10 mg/kg (PM-II), 20 mg/kg (PM-III) and 25 mg/kg (PM-IV). Before and three hours after the injections, the volume of right hind-paw of rats was measured using a plethysmometer. Hepatoprotective Activity: The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Control, CCl4 and reference groups received isotonic saline solution, CCl4 and silibinin, respectively. Plantago major groups received CCl4 (0.8 ml/kg) and PM in doses of 10, 20 and 25 mg/kg, respectively for seven days. Blood samples and liver were collected on the 8th day after the animals were killed. Results: Plantago major had an anti-inflammatory effect matching to that of control group at doses of 20 and 25 mg/kg. It was found that reduction in the inflammation was 90.01% with indomethacin, 3.10% with PM-I, 41.56% with PM-II, 45.87% with PM-III and 49.76% with PM-IV. Median effective dose (ED50) value of PM was found to be 7.507 mg/kg. Plantago major (25 mg/kg) significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the PM (25 mg/kg) and CCl4 groups. Conclusion: The results showed that PM had a considerable anti-inflammatory and hepatoprotective activities. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.4103/0253-7613.55211
dc.identifier.endpage 124 en_US
dc.identifier.issn 0253-7613
dc.identifier.issn 1998-3751
dc.identifier.issue 3 en_US
dc.identifier.pmid 20442819
dc.identifier.scopus 2-s2.0-70349329351
dc.identifier.scopusquality Q3
dc.identifier.startpage 120 en_US
dc.identifier.uri https://doi.org/10.4103/0253-7613.55211
dc.identifier.uri https://hdl.handle.net/20.500.14720/9873
dc.identifier.volume 41 en_US
dc.identifier.wos WOS:000269857000006
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Wolters Kluwer Medknow Publications en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Anti-Inflammatory Activity en_US
dc.subject Hepatoprotective Activity en_US
dc.subject Plantago Major L. en_US
dc.subject Rat en_US
dc.title Hepatoprotective and Anti-Inflammatory Activities of Plantago Major L en_US
dc.type Article en_US

Files