Hepatoprotective and Anti-Inflammatory Activities of Plantago Major L
dc.authorid | Erten, Remzi/0000-0001-7775-5792 | |
dc.authorid | Oner, Ahmet Cihat/0000-0001-6614-4347 | |
dc.authorscopusid | 7003316142 | |
dc.authorscopusid | 7005912992 | |
dc.authorscopusid | 24461417500 | |
dc.authorscopusid | 24177780200 | |
dc.authorscopusid | 55391495500 | |
dc.authorscopusid | 7103213356 | |
dc.authorwosid | Ozbek, Hanefi/O-3472-2019 | |
dc.authorwosid | Cengiz, Nureddin/A-4949-2018 | |
dc.authorwosid | Erten, Remzi/V-5175-2019 | |
dc.authorwosid | Öner, Ahmet Cihat/Aae-2852-2021 | |
dc.authorwosid | Turel, Idris/Lwj-9996-2024 | |
dc.contributor.author | Turel, Idris | |
dc.contributor.author | Ozbek, Hanefi | |
dc.contributor.author | Erten, Remzi | |
dc.contributor.author | Oner, Ahmet Cihat | |
dc.contributor.author | Cengiz, Nureddin | |
dc.contributor.author | Yilmaz, Orhan | |
dc.date.accessioned | 2025-05-10T17:19:39Z | |
dc.date.available | 2025-05-10T17:19:39Z | |
dc.date.issued | 2009 | |
dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
dc.department-temp | [Turel, Idris; Oner, Ahmet Cihat; Yilmaz, Orhan] Yuzuncu Yil Univ, Dept Pharmacol & Toxicol, TR-65300 Van, Turkey; [Ozbek, Hanefi] Yuzuncu Yil Univ, Dept Pharmacol, TR-65300 Van, Turkey; [Erten, Remzi] Yuzuncu Yil Univ, Dept Pathol, TR-65300 Van, Turkey; [Cengiz, Nureddin] Yuzuncu Yil Univ, Dept Histol Embryol, TR-65300 Van, Turkey | en_US |
dc.description | Erten, Remzi/0000-0001-7775-5792; Oner, Ahmet Cihat/0000-0001-6614-4347 | en_US |
dc.description.abstract | Objective: The aim of this study was to investigate anti-inflammatory and hepatoprotective activities of Plantago major L. (PM). Materials and Methods: Anti-inflammatory activity: Control and reference groups were administered isotonic saline solution (ISS) and indomethacin, respectively. Plantago major groups were injected PM in doses of 5 mg/kg (PM-I), 10 mg/kg (PM-II), 20 mg/kg (PM-III) and 25 mg/kg (PM-IV). Before and three hours after the injections, the volume of right hind-paw of rats was measured using a plethysmometer. Hepatoprotective Activity: The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Control, CCl4 and reference groups received isotonic saline solution, CCl4 and silibinin, respectively. Plantago major groups received CCl4 (0.8 ml/kg) and PM in doses of 10, 20 and 25 mg/kg, respectively for seven days. Blood samples and liver were collected on the 8th day after the animals were killed. Results: Plantago major had an anti-inflammatory effect matching to that of control group at doses of 20 and 25 mg/kg. It was found that reduction in the inflammation was 90.01% with indomethacin, 3.10% with PM-I, 41.56% with PM-II, 45.87% with PM-III and 49.76% with PM-IV. Median effective dose (ED50) value of PM was found to be 7.507 mg/kg. Plantago major (25 mg/kg) significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the PM (25 mg/kg) and CCl4 groups. Conclusion: The results showed that PM had a considerable anti-inflammatory and hepatoprotective activities. | en_US |
dc.description.woscitationindex | Science Citation Index Expanded | |
dc.identifier.doi | 10.4103/0253-7613.55211 | |
dc.identifier.endpage | 124 | en_US |
dc.identifier.issn | 0253-7613 | |
dc.identifier.issn | 1998-3751 | |
dc.identifier.issue | 3 | en_US |
dc.identifier.pmid | 20442819 | |
dc.identifier.scopus | 2-s2.0-70349329351 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.startpage | 120 | en_US |
dc.identifier.uri | https://doi.org/10.4103/0253-7613.55211 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14720/9873 | |
dc.identifier.volume | 41 | en_US |
dc.identifier.wos | WOS:000269857000006 | |
dc.identifier.wosquality | Q3 | |
dc.language.iso | en | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Anti-Inflammatory Activity | en_US |
dc.subject | Hepatoprotective Activity | en_US |
dc.subject | Plantago Major L. | en_US |
dc.subject | Rat | en_US |
dc.title | Hepatoprotective and Anti-Inflammatory Activities of Plantago Major L | en_US |
dc.type | Article | en_US |