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Differential Effects of Nebivolol and Atenolol on Transmitral Diastolic Filling Parameters in Patients With Essential Hypertension

dc.authorid Gumrukcuoglu, Hasan Ali/0000-0002-5972-9870
dc.authorid Gunes, Yilmaz/0000-0003-3817-851X
dc.authorscopusid 35520560800
dc.authorscopusid 23566674800
dc.authorscopusid 23566588300
dc.authorscopusid 15047911000
dc.authorscopusid 55964246400
dc.authorwosid Gunes, Yilmaz/Abg-5204-2021
dc.authorwosid Guntekin, Unal/C-7787-2016
dc.authorwosid Gunes, Yilmaz/Y-6512-2018
dc.contributor.author Tuncer, Mustafa
dc.contributor.author Guntekin, Unal
dc.contributor.author Gunes, Yilmaz
dc.contributor.author Gumrukcuoglu, Hasan Ali
dc.contributor.author Eryonucu, Beyhan
dc.date.accessioned 2025-05-10T17:27:03Z
dc.date.available 2025-05-10T17:27:03Z
dc.date.issued 2008
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Tuncer, Mustafa; Guntekin, Unal; Gunes, Yilmaz; Gumrukcuoglu, Hasan Ali] Yuzunci Yil Univ, Fac Med, Dept Cardiol, Van, Turkey; [Eryonucu, Beyhan] Fatih Univ, Fac Med, Dept Cardiol, Ankara, Turkey en_US
dc.description Gumrukcuoglu, Hasan Ali/0000-0002-5972-9870; Gunes, Yilmaz/0000-0003-3817-851X en_US
dc.description.abstract Introduction: Impaired left ventricular (LV) diastolic relaxation, detected by pulsed Doppler echocardiography, is predictive of a higher incidence of major cardiovascular events in hypertensive patients. An improvement in LV diastolic function is an important goal of treatment. However, treatment of LV diastolic dysfunction remains empirical. The objective of our study was to compare the short-term effects of nebivolol and atenolol on Doppler diastolic filling parameters in hypertensive patients. Methods: A total of 32 patients with mild-to-moderate hypertension were enrolled in the study. The patients were randomly assigned to receive treatment with either nebivolol (5 mg/day) or atenolol (50 mg/day) for 1 month. Diastolic filling parameters, with pulsed-wave Doppler transmitral flow velocities, were measured 1 day before and 1 month after treatment. Results: Compared with baseline, both agents significantly decreased heart rate and blood pressure. However, there was no significant difference in pre-and post-treatment values between the nebivolol and atenolol groups. Both drugs significantly improved LV transmitral flow measured by early diastolic flow/atrial contraction signal (E/A) ratio, decreased deceleration time (DT) and isovolumetric contraction time (IVRT), but post-treatment improvement in E/A, DT and IVRT values was more significant with nebivolol compared with atenolol (P=0.05, P=0.05 and P=0.003, respectively). Conclusion: Although treatment with nebivolol or atenolol results in improved LV transmitral diastolic function filling parameters (E/A ratio, IVRT and DT), nebivolol has a greater effect compared with atenolol in patients with mild-to-moderate hypertension. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1007/s12325-008-0065-3
dc.identifier.endpage 626 en_US
dc.identifier.issn 0741-238X
dc.identifier.issn 1865-8652
dc.identifier.issue 6 en_US
dc.identifier.pmid 18563311
dc.identifier.scopus 2-s2.0-58149340108
dc.identifier.scopusquality Q1
dc.identifier.startpage 619 en_US
dc.identifier.uri https://doi.org/10.1007/s12325-008-0065-3
dc.identifier.uri https://hdl.handle.net/20.500.14720/11876
dc.identifier.volume 25 en_US
dc.identifier.wos WOS:000257390500007
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Springer en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Atenolol en_US
dc.subject Diastolic Function en_US
dc.subject Nebivolol en_US
dc.title Differential Effects of Nebivolol and Atenolol on Transmitral Diastolic Filling Parameters in Patients With Essential Hypertension en_US
dc.type Article en_US

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