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Protective Effect of Modified Glucomannans and Organic Selenium Against Antioxidant Depletion in the Chicken Liver Due To T-2 Toxin-Contaminated Feed Consumption

dc.authorid Surai, Peter/0000-0002-5012-8681
dc.authorid Pappas, Athanasios C./0000-0002-9586-8106
dc.authorscopusid 6507970048
dc.authorscopusid 8643947000
dc.authorscopusid 8633434800
dc.authorscopusid 7006869426
dc.authorscopusid 7005199156
dc.authorwosid Surai, Peter/T-6183-2019
dc.authorwosid Karadas, Filiz/K-2750-2016
dc.authorwosid Pappas, Athanasios C./Aad-7262-2019
dc.contributor.author Dvorska, Julia E.
dc.contributor.author Pappas, Athanasios C.
dc.contributor.author Karadas, Filiz
dc.contributor.author Speake, Brian K.
dc.contributor.author Surai, Peter F.
dc.date.accessioned 2025-05-10T17:29:55Z
dc.date.available 2025-05-10T17:29:55Z
dc.date.issued 2007
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Avian Sci Res Ctr, SAC, Edinburgh, Midlothian, Scotland; Sumy Natl Univ, Sumy, Ukraine; Univ Yuzuncu, Fac Agr, Dept Anim Sci, Van, Turkey; Sant Istvan Univ, Dept Nutr, Godollo, Hungary en_US
dc.description Surai, Peter/0000-0002-5012-8681; Pappas, Athanasios C./0000-0002-9586-8106 en_US
dc.description.abstract The aim of this work was to assess the effect of T-2 toxin on the antioxidant status of the chicken and to study possible protective effects of modified glucomannan (Mycosorb (TM)) and organic selenium (Sel-Plex (TM)). Inclusion of T-2 toxin in the chickens' diet (8.1 mg/kg for 21 days) was associated with significant decreases in the concentrations of selenium (Se)(by 32.2%), et-tocopherol (by 41.4%), total carotenoids (by 56.5%), ascorbic acid (by 43.5%) and reduced glutathione (by 56.3%) in the liver, as well as a decrease in the hepatic activity of Se-dependent glutathione peroxidase (Se-GSH-Px) (by 36.8%). However, inclusion of modified glucomannans into the T-2 toxin-contaminated diet provided a partial protection against the detrimental effects of the mycotoxin on the antioxidant defences in the chicken liver. For example, the Se concentration in the liver was restored completely, although the Se-GSH-Px activity in the liver increased to only 81% of its control value. These protective effects of modified glucomannas were associated with a 45% reduction of lipid peroxidation in the liver in comparison to the effects of T-2 toxin alone. A combination of modified glucomannas with organic Se was shown to provide further protection against toxin-induced antioxidant depletion and lipid peroxidation in the chicken liver. Thus, the data clearly indicate a major protective effect of the mycotoxin-binder in combination with organic Se against the detrimental consequences of T-2 toxin-contaminated feed consumption by growing chickens. (c) 2007 Elsevier Inc. All rights reserved. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1016/j.cbpc.2007.02.005
dc.identifier.endpage 587 en_US
dc.identifier.issn 1532-0456
dc.identifier.issue 4 en_US
dc.identifier.pmid 17350343
dc.identifier.scopus 2-s2.0-34247516864
dc.identifier.scopusquality Q2
dc.identifier.startpage 582 en_US
dc.identifier.uri https://doi.org/10.1016/j.cbpc.2007.02.005
dc.identifier.uri https://hdl.handle.net/20.500.14720/12505
dc.identifier.volume 145 en_US
dc.identifier.wos WOS:000246935300008
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Elsevier Science inc en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Antioxidants en_US
dc.subject Chicken en_US
dc.subject Glucomannan en_US
dc.subject Mycotoxin en_US
dc.subject Peroxidation en_US
dc.subject Selenium en_US
dc.subject T-2 Toxin en_US
dc.title Protective Effect of Modified Glucomannans and Organic Selenium Against Antioxidant Depletion in the Chicken Liver Due To T-2 Toxin-Contaminated Feed Consumption en_US
dc.type Article en_US

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