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Effect of Crush and Axotomy of Phrenic Nerves on Oxidative Stress in Diaphragm Muscle of Rats

dc.authorscopusid 6505748936
dc.authorscopusid 23097741000
dc.authorscopusid 7003988714
dc.authorscopusid 56259656000
dc.authorscopusid 55391495500
dc.authorscopusid 6701581425
dc.authorwosid Meral, Ismail/O-7139-2019
dc.authorwosid Cengiz, Nureddin/A-4949-2018
dc.authorwosid Kavak, Servet/Abb-6429-2020
dc.contributor.author Sayir, Fuat
dc.contributor.author Kavak, Servet
dc.contributor.author Meral, Ismail
dc.contributor.author Demir, Halit
dc.contributor.author Cengiz, Nurettin
dc.contributor.author Cobanoglu, Ufuk
dc.date.accessioned 2025-05-10T16:46:37Z
dc.date.available 2025-05-10T16:46:37Z
dc.date.issued 2012
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Sayir, Fuat; Cobanoglu, Ufuk] Yuzuncu Yil Univ, Fac Med, Dept Thorac Surg, TR-65100 Van, Turkey; [Kavak, Servet] Yuzuncu Yil Univ, Fac Med, Dept Biophys, TR-65100 Van, Turkey; [Meral, Ismail] Yuzuncu Yil Univ, Fac Med, Dept Physiol, TR-65100 Van, Turkey; [Demir, Halit] Yuzuncu Yil Univ, Fac Sci, Div Biochem, Dept Chem, TR-65100 Van, Turkey; [Cengiz, Nurettin] Yuzuncu Yil Univ, Fac Sci, Dept Histol & Embryol, TR-65100 Van, Turkey en_US
dc.description.abstract Introduction: In this study we investigated the effect of crush and axotomy of phrenic nerves on oxidative stress and antioxidant enzyme activities in rat diaphragm muscle. Methods: The animals in the first group were not crushed or axotomized and served as controls. Phrenic nerves of the rats in the second and third groups were crushed or axotomized in the diaphragm muscle. Results: The malondialdehyde level increased in diaphragm muscles after both crush and axotomy. The antioxidant enzymes, such as superoxide dismutase, glutathione peroxidase, carbonic anhydrase, and catalase, decreased in diaphragm muscles after both crush and axotomy. Conclusions: Crushing or axotomizing the phrenic nerves may produce oxidative stress in the diaphragm muscle of the rat by increasing lipid peroxidation and decreasing antioxidant enzyme activities. Muscle Nerve, 2012 en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1002/mus.22312
dc.identifier.endpage 415 en_US
dc.identifier.issn 0148-639X
dc.identifier.issn 1097-4598
dc.identifier.issue 3 en_US
dc.identifier.pmid 22334176
dc.identifier.scopus 2-s2.0-84857067625
dc.identifier.scopusquality Q2
dc.identifier.startpage 412 en_US
dc.identifier.uri https://doi.org/10.1002/mus.22312
dc.identifier.uri https://hdl.handle.net/20.500.14720/1209
dc.identifier.volume 45 en_US
dc.identifier.wos WOS:000300684600013
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Antioxidant Enzyme en_US
dc.subject Diaphragm Muscle en_US
dc.subject Oxidative Stress en_US
dc.subject Phrenic Nerve Degeneration en_US
dc.subject Rat en_US
dc.title Effect of Crush and Axotomy of Phrenic Nerves on Oxidative Stress in Diaphragm Muscle of Rats en_US
dc.type Article en_US

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