YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.
 

Fast and Simple Voltammetric Sensing of Avanafil in the Pharmaceutical Formulation by Using Unmodified Boron-Doped Diamond Electrode

No Thumbnail Available

Date

2024

Journal Title

Journal ISSN

Volume Title

Publisher

Iapc Publishing

Abstract

Background and purpose: Erectile dysfunction is a common issue among adult males involving difficulty in maintaining an erection, and it is often treated with fast -acting, low -side -effect drugs like avanafil (AVN), among other phosphodiesterase-5 inhibitors. Hence, developing fast, simple, and sensitive methods to detect AVN is crucial. Experimental approach: This study conducts an electroanalytical inquiry and provides a new voltammetric method for accurately analyzing AVN utilizing a boron -doped diamond (BDD) electrode without any modifications. Key results: In the Britton -Robinson buffer (BR, 0.04 mol L-1, -1 , pH 4.0), cyclic voltammetry showed a clearly defined and irreversible anodic peak at around +1.44 V relative to Ag/AgCl. The pH of the solution was shown to have an impact on the voltammetric signals of the oxidation peaks. A good linear response for AVN quantification was achieved using square -wave voltammetry. This was done in a 0.04 mol L-1 BR (pH 4.0) solution at a potential of +1.33 V ( vs. Ag/AgCl). The method exhibited a wide dynamic range of 0.5 to 30.0 p.g mL-1 -1 (1.0 to 62 p.mol L-1) -1 ) and a low limit of detection of 0.14 p.g mL-1 -1 (0.29 p.mol L-1). -1 ). The method proposed demonstrated suitability for determining AVN content in pharmaceutical formulations. The accuracy of the approach was demonstrated by comparing the results obtained using the developed method with those achieved using the UV-Vis spectrometry method. Conclusion: Our method simplifies the analytical process by eliminating the need for electrode modification, reducing both time and resource requirements while enhancing overall feasibility. (c) 2024 by the authors. This article is an open -access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/4.0/ ).

Description

Barzani, Hemn Abdulazeez Hakeem/0000-0002-1875-7760

Keywords

Electrochemical Sensing, Drug Analysis, Square-Wave Voltammetry

Turkish CoHE Thesis Center URL

WoS Q

N/A

Scopus Q

Q2

Source

Volume

12

Issue

3

Start Page

529

End Page

542