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Cytogenetic and Oxidative Status of Cultured Lymphocytes After Exposure To Extracts From Rhizopogon Mushrooms (Agaricomycetes) in Vitro

dc.authorscopusid 55098881900
dc.authorscopusid 57222724488
dc.authorscopusid 7102936166
dc.authorscopusid 7102214656
dc.authorscopusid 57211230574
dc.authorwosid Emsen, Bugrahan/T-2000-2017
dc.authorwosid Kaya, Abdullah/G-3028-2010
dc.contributor.author Emsen, B.
dc.contributor.author Turel, A.
dc.contributor.author Kaya, A.
dc.contributor.author Aslan, A.
dc.contributor.author Engin, T.
dc.date.accessioned 2025-05-10T17:03:11Z
dc.date.available 2025-05-10T17:03:11Z
dc.date.issued 2021
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp Emsen B., Department of Biology, Kamil Özdağ Faculty of Science, Karamanoğlu Mehmetbey University, Karaman, Turkey; Turel A., Department of Biology, Kamil Özdağ Faculty of Science, Karamanoğlu Mehmetbey University, Karaman, Turkey; Kaya A., Department of Biology, Faculty of Science, Gazi University, Ankara, Turkey; Aslan A., Department of Pharmacology, Faculty of Pharmacy, Van Yüzüncü Yıl University, Van, Turkey, Department of Biology, Faculty of Arts and Science, Kyrgyz-Turkish Manas University, Bishkek, Kyrgyzstan; Engin T., Department of Physiology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey en_US
dc.description.abstract In this study, acetone and water extracts obtained from edible mushrooms, Rhizopogon luteolus Fr. and Rh. roseolus (Corda) Th. Fr., containing important bioactive components were used. Total antioxidant capacity (TAC) and total oxidative stress (TOS) levels were examined on human peripheral lymphocyte culture treated with the respective extracts. Levels of genetic damage and cytotoxic effects of the respective extracts on lymphocytes were also tested. In general, when TAC levels of the extracts on cells were examined, a concentration-dependent increase was observed; a negative correlation was found between TOS data and concentration. Genotoxicity tests (chromosome aberration and micronucleus analysis) revealed that the concentrations of the extract applications did not significantly (P > 0.05) change genotoxicity on human peripheral lymphocyte culture compared to the negative control. Considering all of the results obtained, it was determined that applications of Rh. luteolus and Rh. roseolus extracts, especially at concentrations of 50 and 100 mg/L, increased the TAC value of lymphocytes, which play an important role in the human immune system, without causing genetic or oxidative stress. © 2021 by Begell House, Inc. www.begellhouse.com. en_US
dc.description.sponsorship Karamano?lu Mehmetbey University Scientific Research Projects Commission; Karamanoğlu Mehmetbey University Scientific Research Projects Commission, (06-YL-19) en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1615/IntJMedMushrooms.2021037653
dc.identifier.endpage 77 en_US
dc.identifier.issn 1521-9437
dc.identifier.issue 3 en_US
dc.identifier.pmid 33822500
dc.identifier.scopus 2-s2.0-85103824297
dc.identifier.scopusquality Q3
dc.identifier.startpage 67 en_US
dc.identifier.uri https://doi.org/10.1615/IntJMedMushrooms.2021037653
dc.identifier.uri https://hdl.handle.net/20.500.14720/5631
dc.identifier.volume 23 en_US
dc.identifier.wos WOS:000637192500001
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Begell House Inc. en_US
dc.relation.ispartof International Journal of Medicinal Mushrooms en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Antioxidant en_US
dc.subject Cytotoxicity en_US
dc.subject Fungus en_US
dc.subject Genotoxicity en_US
dc.subject Medicinal Mushrooms en_US
dc.subject Oxidative Stress en_US
dc.subject Rhizopogon Mushrooms en_US
dc.title Cytogenetic and Oxidative Status of Cultured Lymphocytes After Exposure To Extracts From Rhizopogon Mushrooms (Agaricomycetes) in Vitro en_US
dc.type Article en_US

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