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Assessment of the Effect of Sodium Tetraborate on Oxidative Stress, Inflammation, and Apoptosis in Lead-Induced Nephrotoxicity

dc.authorid Bengu, Aydin Sukru/0000-0002-7635-4855
dc.authorid Keles, Omer Faruk/0000-0002-7869-5311
dc.authorid Melek, Sule/0000-0002-0677-722X
dc.authorscopusid 18539360300
dc.authorscopusid 18633524100
dc.authorscopusid 57203188169
dc.authorscopusid 57925656800
dc.authorscopusid 57202435955
dc.authorscopusid 57195562796
dc.authorscopusid 57195562796
dc.authorwosid Bengu, Aydin/Gpp-4213-2022
dc.authorwosid Melek, Şule/Lte-8769-2024
dc.authorwosid Karagözoğlu, Fatma/Jcp-4022-2023
dc.contributor.author Yaman, Turan
dc.contributor.author Akkoyun, H. Turan
dc.contributor.author Akkoyun, Mahire Bayramoglu
dc.contributor.author Karagozoglu, Fatma
dc.contributor.author Melek, Sule
dc.contributor.author Keles, Omer Faruk
dc.contributor.author Bengu, Aydin Sukru
dc.date.accessioned 2025-05-10T17:22:57Z
dc.date.available 2025-05-10T17:22:57Z
dc.date.issued 2025
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Yaman, Turan; Keles, Omer Faruk] Van Yuzuncu Yil Univ, Fac Vet Med, Dept Pathol, Van, Turkiye; [Akkoyun, H. Turan] Siirt Univ, Fac Vet Med, Dept Physiol, TR-56100 Siirt, Turkiye; [Akkoyun, Mahire Bayramoglu] Siirt Univ, Fac Vet Med, Dept Biochem, Siirt, Turkiye; [Karagozoglu, Fatma] Dokuz Eylul Univ, Fac Vet Med, Dept Anim Nutr & Nutr Dis, Izmir, Turkiye; [Melek, Sule] Univ Bingol, Fac Vet Med, Dept Surg, Bingol, Turkiye; [Bengu, Aydin Sukru] Bingol Univ, Vocat Sch Hlth Serv, Bingol, Turkiye en_US
dc.description Bengu, Aydin Sukru/0000-0002-7635-4855; Keles, Omer Faruk/0000-0002-7869-5311; Melek, Sule/0000-0002-0677-722X en_US
dc.description.abstract Exposure to Pb, a toxic heavy metal, is a risk factor for renal damage. Borax, an essential trace element in cellular metabolism, is a naturally occurring compound found in many foods. This study investigated the effects of sodium tetraborate (ST), a source of borax, on renal oxidative stress and inflammation in rats exposed to Pb. Wistar Albino rats (n = 24) were divided into four groups: Control (0.5 mL, i.p. isotonic), Pb (50 mg/kg/day/i.p.), ST (4.0 mg/kg/day/oral), and Pb + ST groups. At the end of the five-day experimental period, kidney tissue samples were obtained and analyzed. Histopathologically, the Pb-induced damage observed in the Pb group improved in the Pb + ST group. Immunohistochemically, Pb administration increased the expression of inducible nitric oxide synthase, cyclooxygenase-2, and caspase-3. When evaluated biochemically, Pb application inhibited catalase and glutathione peroxidase (GSH-Px) enzyme activities and activated superoxide dismutase enzyme activity. An increase in malondialdehyde levels was considered an indicator of damage. ST application increases glutathione peroxidase enzyme activity and decreased malondialdehyde levels. These results indicate that ST might play a protective role against Pb-induced renal damage via the upregulation of renal tissue antioxidants and cyclooxygenase-2, inducible nitric oxide synthase, and caspase-3 immunoexpression. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1080/01480545.2024.2358067
dc.identifier.endpage 162 en_US
dc.identifier.issn 0148-0545
dc.identifier.issn 1525-6014
dc.identifier.issue 1 en_US
dc.identifier.pmid 38804252
dc.identifier.scopus 2-s2.0-85194567522
dc.identifier.scopusquality Q2
dc.identifier.startpage 150 en_US
dc.identifier.uri https://doi.org/10.1080/01480545.2024.2358067
dc.identifier.uri https://hdl.handle.net/20.500.14720/10727
dc.identifier.volume 48 en_US
dc.identifier.wos WOS:001233830300001
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Taylor & Francis Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Antioxidants en_US
dc.subject Caspase-3 en_US
dc.subject Cyclooxygenase-2 en_US
dc.subject Inducible Nitric Oxide Synthase en_US
dc.subject Lead en_US
dc.subject Sodium Tetraborate en_US
dc.title Assessment of the Effect of Sodium Tetraborate on Oxidative Stress, Inflammation, and Apoptosis in Lead-Induced Nephrotoxicity en_US
dc.type Article en_US

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