Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats
| dc.authorid | Aksoy, Mehmet/0000-0003-0867-8660 | |
| dc.authorid | Alp, Hamit Hakan/0000-0002-9202-4944 | |
| dc.authorid | Ahiskalioglu, Ali/0000-0002-8467-8171 | |
| dc.authorscopusid | 55808259900 | |
| dc.authorscopusid | 55512448100 | |
| dc.authorscopusid | 7103036508 | |
| dc.authorscopusid | 56338858700 | |
| dc.authorscopusid | 56444283800 | |
| dc.authorscopusid | 34874841600 | |
| dc.authorscopusid | 56444330700 | |
| dc.authorwosid | Hakan, Hamit/U-2671-2018 | |
| dc.authorwosid | Aksoy, Mehmet/Jkh-6721-2023 | |
| dc.authorwosid | Taghizadehghalehjoughi, Ali/Afd-9473-2022 | |
| dc.authorwosid | Çelik, Mine/Afq-3900-2022 | |
| dc.authorwosid | Çömez, Mehmet/Aad-1535-2021 | |
| dc.authorwosid | Ahiskalioglu, Ali/K-5343-2019 | |
| dc.authorwosid | Ahiskalioglu, Ali/B-7473-2016 | |
| dc.contributor.author | Ahiskalioglu, Ali | |
| dc.contributor.author | Ince, Ilker | |
| dc.contributor.author | Aksoy, Mehmet | |
| dc.contributor.author | Ahiskalioglu, Elif Oral | |
| dc.contributor.author | Comez, Mehmet | |
| dc.contributor.author | Dostbil, Aysenur | |
| dc.contributor.author | Suleyman, Bahadir | |
| dc.date.accessioned | 2025-05-10T17:11:13Z | |
| dc.date.available | 2025-05-10T17:11:13Z | |
| dc.date.issued | 2015 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Ahiskalioglu, Ali; Ince, Ilker; Aksoy, Mehmet; Dostbil, Aysenur; Celik, Mine] Ataturk Univ, Fac Med, Dept Anaesthesiol & Reanimat, TR-25100 Erzurum, Turkey; [Ahiskalioglu, Elif Oral; Comez, Mehmet] Reg Educ & Res Hosp, Dept Anaesthesiol & Reanimat, TR-25100 Erzurum, Turkey; [Alp, Hamit Hakan] Yil Univ, Fac Med, Dept Biochem, TR-65000 Van, Turkey; [Coskun, Resit] Bayburt State Hosp, Dept Cardiol, TR-69000 Bayburt, Turkey; [Taghizadehghalehjoughi, Ali] Ataturk Univ, Fac Med, Dept Pharmacol, TR-25100 Erzurum, Turkey; [Suleyman, Bahadir] Recep Tayyip Erdogan Univ, Fac Med, Dept Pharmacol, TR-53000 Rize, Turkey | en_US |
| dc.description | Aksoy, Mehmet/0000-0003-0867-8660; Alp, Hamit Hakan/0000-0002-9202-4944; Ahiskalioglu, Ali/0000-0002-8467-8171 | en_US |
| dc.description.abstract | This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) on single dose ketamine (60 mg/kg)-induced cardiotoxicity. In group B, we investigated the effect of metyrosine and metoprolol, which were given together with ketamine for 30 days. In group C, we investigated the effect of metyrosine and metoprolol given 15 days before ketamine and 30 days together with ketamine on ketamine cardiotoxicity. By the end of this process, we evaluated the effects of the levels of oxidant-antioxidant parameters such as MDA, MPO, 8-OHGua, tGSH, and SOD in addition to CK-MB and TP I on cardiotoxicity in rat heart tissue. The experimental results show that metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.1007/s12012-014-9301-z | |
| dc.identifier.endpage | 344 | en_US |
| dc.identifier.issn | 1530-7905 | |
| dc.identifier.issn | 1559-0259 | |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.pmid | 25503950 | |
| dc.identifier.scopus | 2-s2.0-84942371683 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 336 | en_US |
| dc.identifier.uri | https://doi.org/10.1007/s12012-014-9301-z | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/7681 | |
| dc.identifier.volume | 15 | en_US |
| dc.identifier.wos | WOS:000361605900005 | |
| dc.identifier.wosquality | Q2 | |
| dc.language.iso | en | en_US |
| dc.publisher | Humana Press inc | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Antioxidant | en_US |
| dc.subject | Cardiotoxicity | en_US |
| dc.subject | Ketamine | en_US |
| dc.subject | Metoprolol | en_US |
| dc.subject | Metyrosine | en_US |
| dc.subject | Oxidant | en_US |
| dc.subject | Rat | en_US |
| dc.title | Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats | en_US |
| dc.type | Article | en_US |