Effect of Nigella Sativa on Glucose Concentration, Lipid Peroxidation, Anti-Oxidant Defence System and Liver Damage in Experimentally-Induced Diabetic Rabbits
| dc.authorid | Mert, Nihat/0000-0001-7185-3316 | |
| dc.authorid | Yener, Zabit/0000-0002-6365-5843 | |
| dc.authorid | Kahraman, Tahir/0000-0003-4238-8528 | |
| dc.authorscopusid | 7003988714 | |
| dc.authorscopusid | 56087055000 | |
| dc.authorscopusid | 6602622021 | |
| dc.authorscopusid | 6601956926 | |
| dc.authorwosid | Meral, Ismail/O-7139-2019 | |
| dc.authorwosid | Mert, Nihat/Hjh-5486-2023 | |
| dc.authorwosid | Kahraman, Tahi̇r/Aat-5781-2020 | |
| dc.contributor.author | Meral, I | |
| dc.contributor.author | Yener, Z | |
| dc.contributor.author | Kahraman, T | |
| dc.contributor.author | Mert, N | |
| dc.date.accessioned | 2025-05-10T17:37:57Z | |
| dc.date.available | 2025-05-10T17:37:57Z | |
| dc.date.issued | 2001 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | Yuzuncu Yil Univ, Dept Physiol Vet Med, Van, Turkey; Yuzuncu Yil Univ, Dept Pathol Vet Med, Van, Turkey; Yuzuncu Yil Univ, Dept Biochem Vet Med, Van, Turkey | en_US |
| dc.description | Mert, Nihat/0000-0001-7185-3316; Yener, Zabit/0000-0002-6365-5843; Kahraman, Tahir/0000-0003-4238-8528 | en_US |
| dc.description.abstract | This Study was carried out to investigate whether Nigella sativa could decrease the lipid peroxidation, increase the anti-oxidant defence system and also prevent the lipid-peroxidation-induced Ever damage in experimentally induced diabetic rabbits. Fifteen New Zealand male rabbits were divided into three experimental groups: control, diabetic and diabetic and N. sativa-treated. The diabetes mellitus (DM) was induced in the rabbits using 150 mg/kg of 10% alloxan. The diabetic + N. sativa-treated group was given extract of N sativa seeds orally every day for 2 months after induction of D-M. At the end of the 2-month experiment, blood samples were collected to measure malondialdehyde (MDA), glutathione (GSH), ceruloplasmin and glucose concentration, and livers were harvested for histopathological analysis, Treatment with N sativa decreased the elevated glucose and MDA concentrations, increased the lowered GSH and ceruloplasmin concentrations, and prevented lipid-peroxidation-induced Ever damage in diabetic rabbits. It was concluded that N sativa might be used in diabetic patients to prevent lipid peroxidation, increase anti-oxidant defence system activity, and also prevent liver damage. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.1046/j.1439-0442.2001.00393.x | |
| dc.identifier.endpage | 599 | en_US |
| dc.identifier.issn | 0931-184X | |
| dc.identifier.issue | 10 | en_US |
| dc.identifier.pmid | 11848252 | |
| dc.identifier.scopus | 2-s2.0-0035752777 | |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.startpage | 593 | en_US |
| dc.identifier.uri | https://doi.org/10.1046/j.1439-0442.2001.00393.x | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/14517 | |
| dc.identifier.volume | 48 | en_US |
| dc.identifier.wos | WOS:000173185500004 | |
| dc.identifier.wosquality | N/A | |
| dc.language.iso | en | en_US |
| dc.publisher | Blackwell verlag Gmbh | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Effect of Nigella Sativa on Glucose Concentration, Lipid Peroxidation, Anti-Oxidant Defence System and Liver Damage in Experimentally-Induced Diabetic Rabbits | en_US |
| dc.type | Article | en_US |