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The Effect of Diplotaenia Turcica Root Extract in Streptozotocin-Induced Diabetic Rats

dc.authorid Ozdek, Ugur/0000-0002-0709-1545
dc.authorscopusid 57205351691
dc.authorscopusid 16310940800
dc.authorscopusid 15764722200
dc.authorwosid Özdek, Ugur/Aaa-3770-2022
dc.authorwosid Yildirim, Serkan/Aah-6721-2020
dc.contributor.author Ozdek, Ugur
dc.contributor.author Yildirim, Serkan
dc.contributor.author Deger, Yeter
dc.date.accessioned 2025-05-10T17:04:31Z
dc.date.available 2025-05-10T17:04:31Z
dc.date.issued 2020
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Ozdek, Ugur] Yuzuncu Yil Univ, Vocat Sch Hlth Serv, Van, Turkey; [Yildirim, Serkan] Ataturk Univ, Fac Vet Med, Dept Pathol, Erzurum, Turkey; [Deger, Yeter] Yuzuncu Yil Univ, Fac Vet Med, Dept Biochem, Van, Turkey en_US
dc.description Ozdek, Ugur/0000-0002-0709-1545 en_US
dc.description.abstract Background: Diplotaenia turcica has been used traditionally to diabetes treatment. In this study, the effects of D. turcica root extract (DT) on diabetes mellitus induced by streptozotocin (STZ) were investigated. Materials and methods: In this study, 78 male rats were used, rats were divided into 9 groups randomly. In diabetic groups, STZ was given a single dose of 45 mg/kg by intraperitoneally. DT (50,100 and 200 mg/kg) and glibenclamide (5 mg/kg) were given by orally. Blood and pancreas tissue samples were taken for biochemical and pathological tests. Results: It was found that glucose levels decreased, and insulin levels increased in the treatment groups compared with the diabetes group. In addition, only in 200 mg/kg DT dose group was found to decrease HbA1c levels. Pancreatic tissue analysis showed that MDA levels decreased and GSH levels and CAT, SOD, GSH-Px and GSH-R activities increased in diabetic rats treated with DT. Histopathological and immunohistochemical examinations of the pancreas showed significant improvements in the treatment with DT. Conclusion: These results clearly show the antioxidant property of DT. The findings of this study showed that increased doses of DT may have a therapeutic effect on STZ-induced pancreatic damage. en_US
dc.description.sponsorship Department of Scientific Research Projects at Van Yuzuncu Yil University [TDK-2016-5378] en_US
dc.description.sponsorship We would like to thank the Department of Scientific Research Projects at Van Yuzuncu Yil University (TDK-2016-5378) for their financial support. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1515/tjb-2018-0411
dc.identifier.issn 0250-4685
dc.identifier.issn 1303-829X
dc.identifier.issue 2 en_US
dc.identifier.scopus 2-s2.0-85086147796
dc.identifier.scopusquality Q4
dc.identifier.uri https://doi.org/10.1515/tjb-2018-0411
dc.identifier.uri https://hdl.handle.net/20.500.14720/6018
dc.identifier.volume 45 en_US
dc.identifier.wos WOS:000596779000011
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Walter de Gruyter Gmbh en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Antioxidant en_US
dc.subject Diabetes Mellitus en_US
dc.subject Diplotaenia Turcica en_US
dc.subject Histopathology en_US
dc.subject Immunohistochemistry en_US
dc.subject Lipid Peroxidation en_US
dc.subject Pancreas en_US
dc.title The Effect of Diplotaenia Turcica Root Extract in Streptozotocin-Induced Diabetic Rats en_US
dc.type Article en_US

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