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Sedative and Anxiolytic Activities of Opuntia Ficus Indica (L.) Mill.: an Experimental Assessment in Mice

dc.authorid Sobarzo-Sanchez, Eduardo/0000-0002-2790-2544
dc.authorid Kupeli Akkol, Esra/0000-0002-5829-7869
dc.authorid Karpuz Agoren, Busra/0000-0001-6095-5210
dc.authorid Ilhan, Mert/0000-0001-5042-3915
dc.authorscopusid 23096992900
dc.authorscopusid 56020070400
dc.authorscopusid 57210468922
dc.authorscopusid 45261107000
dc.authorscopusid 6601935879
dc.authorwosid Akkol, Esra/Abi-4678-2020
dc.authorwosid Karpuz Ağören, Büşra/Jjd-7643-2023
dc.authorwosid Ilhan, Mert/Hlh-6199-2023
dc.authorwosid Sobarzo-Sánchez, Eduardo/B-1507-2012
dc.contributor.author Akkol, Esra Kupeli
dc.contributor.author Ilhan, Mert
dc.contributor.author Karpuz, Busra
dc.contributor.author Genc, Yasin
dc.contributor.author Sobarzo-Sanchez, Eduardo
dc.date.accessioned 2025-05-10T17:04:31Z
dc.date.available 2025-05-10T17:04:31Z
dc.date.issued 2020
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Akkol, Esra Kupeli; Karpuz, Busra] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey; [Ilhan, Mert] Van Yuzuncu Yil Univ, Fac Pharm, Dept Pharmacognosy, TR-65080 Tusba, Van, Turkey; [Genc, Yasin] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey; [Sobarzo-Sanchez, Eduardo] Univ Cent Chile, Fac Ciencias Salud, Inst Invest & Innovac Salud, Santiago 8330507, Chile; [Sobarzo-Sanchez, Eduardo] Univ Santiago de Compostela, Fac Pharm, Dept Organ Chem, Santiago De Compostela 15782, Spain en_US
dc.description Sobarzo-Sanchez, Eduardo/0000-0002-2790-2544; Kupeli Akkol, Esra/0000-0002-5829-7869; Karpuz Agoren, Busra/0000-0001-6095-5210; Ilhan, Mert/0000-0001-5042-3915 en_US
dc.description.abstract Ethnobotanical field surveys revealed the use of fruits of Opuntia ficus indica (L.) Mill. for treating diabetes, burns, bronchial asthma, constipation, kidney stones, and rheumatic pains and as a sedative in Turkish folk medicine. This study aimed to verify the efficacy of the fruits of O. ficus indica experimentally and to define components responsible for the activity using bioassay-guided procedures. The crude methanolic extract of the fruits was sequentially fractionated into five subextracts: n-hexane, dichloromethane, ethyl acetate, n-butanol, and water. Further experiments were carried out on the most active subextract, that is, the ethyl acetate (EtOAc) subextract, which was further subjected to fractionation through successive column chromatographic applications on Sephadex LH-20. For activity assessment, each extract or fraction was submitted to bioassay systems; traction test, fireplace test, hole-board test, elevated plus-maze test, and open-field test were used for sedative and anxiolytic effects, and a thiopental-induced sleeping test was used for the hypnotic effect. Among the subextracts obtained from the methanolic extract, the EtOAc subextract showed significant sedative and anxiolytic effects in the bioassay systems. From the EtOAc subextract, major components were isolated, and their structures were determined as isorhamnetin, isorhamnetin 3-O-glucoside, isorhamnetin 3-O-rutinoside, and kaempferol 3-O-rutinoside using spectral techniques. In conclusion, this study confirmed the claimed use of the plant against anxiety in Turkish folk medicine. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.3390/molecules25081844
dc.identifier.issn 1420-3049
dc.identifier.issue 8 en_US
dc.identifier.pmid 32316321
dc.identifier.scopus 2-s2.0-85083570525
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.3390/molecules25081844
dc.identifier.uri https://hdl.handle.net/20.500.14720/6017
dc.identifier.volume 25 en_US
dc.identifier.wos WOS:000534617500036
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Mdpi en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Anxiolytic en_US
dc.subject Cactaceae en_US
dc.subject Hypnotic en_US
dc.subject Mice en_US
dc.subject Opuntia Ficus Indica en_US
dc.subject Sedative en_US
dc.title Sedative and Anxiolytic Activities of Opuntia Ficus Indica (L.) Mill.: an Experimental Assessment in Mice en_US
dc.type Article en_US

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