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Comparison of Brucellar and Tuberculous Spondylodiscitis Patients: Results of the Multicenter "backbone-1 Study

dc.authorid Balkan, Ilker Inanc/0000-0002-8977-5931
dc.authorid Meric Koc, Meliha/0000-0002-0563-6900
dc.authorid Tuncer Ertem, Gunay/0000-0001-8760-0030
dc.authorid El-Sokkary, Rehab/0000-0002-8135-7671
dc.authorid Yildiz Sevgi, Dilek/0000-0002-6047-4879
dc.authorid Pehlivanoglu, Filiz/0000-0001-9943-6004
dc.authorid Giannitsioti, Efthymia/0000-0003-2715-7457
dc.authorscopusid 7005578733
dc.authorscopusid 55928536800
dc.authorscopusid 6505508467
dc.authorscopusid 55537502600
dc.authorscopusid 23009761400
dc.authorscopusid 36560231700
dc.authorscopusid 6602175753
dc.authorwosid Kaya, Selcuk/Aal-7750-2021
dc.authorwosid Cesur, Sali̇h/Agw-4011-2022
dc.authorwosid Batirel, Ayse/Kuc-6287-2024
dc.authorwosid Guclu, Ertugrul/Aei-3766-2022
dc.authorwosid Karaca, Banu/Hkw-0982-2023
dc.authorwosid Vahaboglu, H/Hhz-1169-2022
dc.authorwosid Erdem, Hakan/O-2462-2013
dc.contributor.author Erdem, Hakan
dc.contributor.author Elaldi, Nazif
dc.contributor.author Batirel, Ayse
dc.contributor.author Aliyu, Sani
dc.contributor.author Sengoz, Gonul
dc.contributor.author Pehlivanoglu, Filiz
dc.contributor.author Vahaboglu, Haluk
dc.date.accessioned 2025-05-10T17:39:57Z
dc.date.available 2025-05-10T17:39:57Z
dc.date.issued 2015
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Erdem, Hakan] Culhane Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey; [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey; [Batirel, Ayse; Ocal, Gulfem] Dr Lao Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Aliyu, Sani] Cambridge Univ Hosp Fdn Trust, Addenbrookes Hosp, Clin Microbiol & Publ Hlth Lab, Cambridge, England; [Sengoz, Gonul; Pehlivanoglu, Filiz] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Ramosaco, Ergys] Univ Hosp Ctr Mother Teresa, Infect Dis Hosp, Tirana, Albania; [Gulsun, Serda; Kaya, Safak] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey; [Tekin, Recep] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey; [Mete, Birgul; Balkan, Ilker Inanc] Istanbul Univ, Cerrahpasa Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Sevgi, Dilek Yildiz] Sisli Etfal Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Giannitsioti, Efthymia; Fragou, Archontoula] Attikon Univ Gen Hosp, Athens Univ Med Sch, Dept Internal Med, Athens, Greece; [Kaya, Selcuk] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey; [Cetin, Birsen] Koc Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Oktenoglu, Tune] Koc Univ, Sch Med, Dept Neurosurg, Istanbul, Turkey; [DoganCelik, Aygul] Trakya Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Edirne, Turkey; [Karaca, Banu] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey; [Horasan, Elif Sahin] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey; [Ulug, Mehmet] Private Umit Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey; [Man, Asuman; Senbayrak, Seniha] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Arslanalp, Esra; Willke, Ayse; Meric-Koc, Meliha] Kocaeli Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kocaeli, Turkey; [Ates-Guler, Selma] Kahramanmaras Sutcu Imam Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-46050 Kahramanmaras, Turkey; [Senol, Sebnem] Celal Bayar Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Manisa, Turkey; [Inan, Dilara] Akdeniz Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-07058 Antalya, Turkey; [Guclu, Ertugrul] Sakarya Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sakarya, Turkey; [Tuncer-Ertem, Gunay; Cesur, Salih] Ankara Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey; [Tasbakan, Meitem] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey; [Cicek-Senturk, Gonul; Asian, Gonul] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey; [Sirmatel, Fatma] Abant Izzet Baysal Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bolu, Turkey; [Kocagoz, Sesin; Kusoglu, Hulya] Acibadem Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Guven, Turner] Ankara Ataturk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey; [Baran, Ali Irfan] Yuzuncu Yil Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Van, Turkey; [Dede, Behiye] Umraniye Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Yilmaz-Karadag, Fatma; Vahaboglu, Haluk] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Kose, Sukran] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey; [Yilmaz, Hava] Ondokuz Mayis Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey; [Algallad, D. Ashraf; El-Sokkary, Rehab] Zagazig Univ Hosp, Infect Control Unit, Az Zagazig, Egypt; [Bekiroglu, Nural] Marmara Univ, Sch Med, Dept Biostat, Istanbul, Turkey en_US
dc.description Balkan, Ilker Inanc/0000-0002-8977-5931; Meric Koc, Meliha/0000-0002-0563-6900; Tuncer Ertem, Gunay/0000-0001-8760-0030; El-Sokkary, Rehab/0000-0002-8135-7671; Yildiz Sevgi, Dilek/0000-0002-6047-4879; Pehlivanoglu, Filiz/0000-0001-9943-6004; Erdem, Hakan/0000-0002-6265-5227; Senbayrak, Seniha/0000-0002-4983-6613; Mete, Bilgul/0000-0001-9091-6087; Vahaboglu, Haluk/0000-0001-8217-1767; Giannitsioti, Efthymia/0000-0003-2715-7457 en_US
dc.description.abstract BACKGROUND CONTEXT: No direct comparison between brucellar spondylodiscitis (BSD) and tuberculous spondylodiscitis (TSD) exists in the literature. PURPOSE: This study aimed to compare directly the clinical features, laboratory and radiological aspects, treatment, and outcome data of patients diagnosed as BSD and TSD. STUDY DESIGN: A retrospective, multinational, and multicenter study was used. PATIENT SAMPLE: A total of 641 (TSD, 314 and BSD, 327) spondylodiscitis patients from 35 different centers in four countries (Turkey, Egypt, Albania, and Greece) were included. OUTCOME MEASURES: The pre- and peri- or post-treatment spinal deformity and neurologic deficit parameters, and mortality were carried out. METHODS: Brucellar spondylodiscitis and TSD groups were compared for demographics, clinical, laboratory, radiological, surgical interventions, treatment, and outcome data. The Student t test and Mann-Whitney U test were used for group comparisons. Significance was analyzed as two sided and inferred at 0.05 levels. RESULTS: The median baseline laboratory parameters including white blood cell count, C-reactive protein, and erythrocyte sedimentation rate were higher in TSD than BSD (p<.0001). Prevertebral, paravertebral, epidural, and psoas abscess formations along with loss of vertebral corpus height and calcification were significantly more frequent in TSD compared with BSD (p<.01). Surgical interventions and percutaneous sampling or abscess drainage were applied more frequently in TSD (p<.0001). Spinal complications including gibbus deformity, kyphosis, and scoliosis, and the number of spinal neurologic deficits, including loss of sensation, motor weakness, and paralysis were significantly higher in the TSD group (p<.05). Mortality rate was 2.22% (7 patients) in TSD, and it was 0.61% (2 patients) in the BSD group (p=.1). CONCLUSIONS: The results of this study show that TSD is a more suppurative disease with abscess formation requiring surgical intervention and characterized with spinal complications. We propose that using a constellation of constitutional symptoms (fever, back pain, and weight loss), pulmonary involvement, high inflammatory markers, and radiological findings will help to differentiate between TSD and BSD at an early stage before microbiological results are available. (C) 2015 Elsevier Inc. All rights reserved. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1016/j.spinee.2015.09.024
dc.identifier.endpage 2517 en_US
dc.identifier.issn 1529-9430
dc.identifier.issn 1878-1632
dc.identifier.issue 12 en_US
dc.identifier.pmid 26386176
dc.identifier.scopus 2-s2.0-84964434615
dc.identifier.scopusquality Q1
dc.identifier.startpage 2509 en_US
dc.identifier.uri https://doi.org/10.1016/j.spinee.2015.09.024
dc.identifier.uri https://hdl.handle.net/20.500.14720/15053
dc.identifier.volume 15 en_US
dc.identifier.wos WOS:000366655100045
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Elsevier Science inc en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Brucellosis en_US
dc.subject Complication en_US
dc.subject Outcome en_US
dc.subject Sequelae en_US
dc.subject Spondylodiscitis en_US
dc.subject Tuberculosis en_US
dc.title Comparison of Brucellar and Tuberculous Spondylodiscitis Patients: Results of the Multicenter "backbone-1 Study en_US
dc.type Article en_US

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