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The Effect of Enamel Matrix Derivatives on Root Coverage: a 12-Month Follow-Up of a Randomized Clinical Trial

dc.authorid Ertugrul, Abdullah Seckin/0000-0002-9973-3161
dc.authorid Sahin Aydinyurt, Hacer/0000-0002-9521-9704
dc.authorscopusid 57192604857
dc.authorscopusid 55539572500
dc.authorscopusid 55317580600
dc.contributor.author Aydinyurt, Hacer Sahin
dc.contributor.author Tekin, Yasin
dc.contributor.author Ertugrul, Abdullah Seckin
dc.date.accessioned 2025-05-10T17:43:35Z
dc.date.available 2025-05-10T17:43:35Z
dc.date.issued 2019
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Aydinyurt, Hacer Sahin] Van Yuzuncu Yil Univ, Fac Dent, Dept Periodontol, Van, Turkey; [Tekin, Yasin] Trakya Univ, Fac Dent, Dept Periodontol, Edirne, Turkey; [Ertugrul, Abdullah Seckin] Izmir Katip Celebi Univ, Fac Dent, Dept Periodontol, Izmir, Turkey en_US
dc.description Ertugrul, Abdullah Seckin/0000-0002-9973-3161; Sahin Aydinyurt, Hacer/0000-0002-9521-9704 en_US
dc.description.abstract Subepithelial connective tissue grafts (SCTGs) with a coronally advanced flap (CAF) are accepted as the gold standard for covering denuded root surfaces. In recent years, enamel matrix derivatives (EMDs) have been used for their regenerative potential in periodontics. The aim of this split-mouth and randomized controlled study was to assess the clinical and aesthetical impacts of EMD application in combination with SCTG+CAF in patients with Miller's Class I and II gingival recessions in contralateral canines of the maxilla. Participants who underwent SCTG+CAF+EMD application were identified as the test group (n = 19) and those who underwent SCTG+CAF as control group (n = 19). The outcome parameters were recession depth/width, root coverage percentage, and root coverage aesthetic score (RES). RES was evaluated by two calibrated blind periodontists one year after the treatment. Statistically significant root coverage percentage was observed at one year post-treatment for both groups (p < 0.05). However, significant differences between the groups were not observed in terms of total RES and complete root coverage rate (p > 0.05). The test group had significantly better results than the control according to the soft tissue texture and mucogingival junction alignment results (p < 0.05). These results indicate that EMDs contribute to the healing of soft tissue without scarring. As a result of better wound healing, the EMD-added group exhibited better results in terms of the harmony of the mucogingival junction between adjacent teeth. This paper is the first split-mouth study in which SCTG+CAF and SCTG+CAF+EMD were compared using RES in bilateral canines. en_US
dc.description.sponsorship University of Van Yuzuncu Yil University (Committee of Research) [2014-SBE-D017]; Faculty of Dentistry at Van Yuzuncu Yil University en_US
dc.description.sponsorship This study was approved by Clinicaltrials.gov. Protocol registration and result system system (NCT03197610). This study was self-funded by the authors and by the University of Van Yuzuncu Yil University (Committee of Research 2014-SBE-D017). The authors thank the Faculty of Dentistry at Van Yuzuncu Yil University for its support. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1590/1807-3107bor-2019.vol33.0006
dc.identifier.issn 1807-3107
dc.identifier.pmid 30758406
dc.identifier.scopus 2-s2.0-85061490705
dc.identifier.scopusquality N/A
dc.identifier.uri https://doi.org/10.1590/1807-3107bor-2019.vol33.0006
dc.identifier.uri https://hdl.handle.net/20.500.14720/15909
dc.identifier.volume 33 en_US
dc.identifier.wos WOS:000468340500006
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Sociedade Brasileira de Pesquisa Odontologica en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Gingival Recession en_US
dc.subject Autrografts en_US
dc.subject Periodontics en_US
dc.title The Effect of Enamel Matrix Derivatives on Root Coverage: a 12-Month Follow-Up of a Randomized Clinical Trial en_US
dc.type Article en_US

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